LiverLearning®: 2018 Webinar: Portal Vein Thrombosis in Cirrhosis: Causes and Consequences

This webinar will focus on the concept of coagulation in cirrhosis; pathophysiology, concept of a rebalanced coagulation state in cirrhosis and the consequences such as portal vein thrombosis. The management of PVT will be discussed.Andres Cardenas (Moderator) Dr. Andrés Cárdenas is currently a Consultant and Clinical Professor of the Institute of Digestive Diseases and Metabolism at Hospital Clinic and University of Barcelona.

The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice

Zhiwen Fan, Luyang Li, Min Li, Xinjian Zhang, Chenzhi Hao, Liming Yu, Sheng Zeng, Huihui Xu, Mingming Fang, Aiguo Shen, Thomas Jenuwein, Yong Xu – 28 February 2017 – Uncontrolled inflammatory response highlights the central theme of nonalcoholic steatohepatitis (NASH), a growing global pandemic. Hepatocytes and macrophages represent two major sources of hepatic inflammation during NASH pathogenesis, contributing to excessive synthesis of proinflammatory mediators. The epigenetic mechanism that accounts for the activation of hepatocytes and macrophages in this process remains obscure.

Evaluation of hepatitis B reactivation among 62,920 veterans treated with oral hepatitis C antivirals

Pamela S. Belperio, Troy A. Shahoumian, Larry A. Mole, Lisa I. Backus – 27 February 2017 – Reactivation of hepatitis B virus (HBV) has been reported in hepatitis C virus–infected individuals receiving direct‐acting antiviral (DAA) therapy. The overall risk among patients with current or prior HBV infection in the context of DAA treatment is unknown. The aim of this evaluation was to identify and characterize HBV reactivation among veterans treated with oral DAA therapy. This retrospective evaluation included 62,290 hepatitis C virus–infected veterans completing oral DAA treatment.

Nonalcoholic fatty liver disease‐related cirrhosis is commonly unrecognized and associated with hepatocellular carcinoma

Luis C. Bertot, Gary P. Jeffrey, Michael Wallace, Gerry MacQuillan, George Garas, Helena L. Ching, Leon A. Adams – 27 February 2017 – Determination of cirrhosis in nonalcoholic fatty liver disease (NAFLD) is important as it alters prognosis and management. We aimed to examine whether cirrhosis was diagnosed incidentally or intentionally in patients with NAFLD.

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