Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit
Yaron Rotman, Brent A. Neuschwander‐Tetri – 2 February 2017
Changing pattern of biliary complications in an evolving liver transplant unit
Ashwin Rammohan, Sanjay Govil, Joy Vargese, Venugopal Kota, Mettu S. Reddy, Mohamed Rela – 2 February 2017 – Biliary complications (BCs) remain a significant cause of morbidity following liver transplantation (LT). This series of 640 LT recipients with a blend of living and deceased donor transplants was analyzed to determine the incidence, risk factors, management protocol, and outcomes in these patients. Review of a prospectively collected database of transplant recipients operated between August 2009 and June 2016 was performed.
Apolipoprotein(a) inhibits hepatitis C virus entry through interaction with infectious particles
Catarina Oliveira, Carole Fournier, Véronique Descamps, Virginie Morel, Corey A. Scipione, Rocco Romagnuolo, Marlys L. Koschinsky, Agnès Boullier, Paulo Marcelo, Jean‐Marc Domon, Etienne Brochot, Gilles Duverlie, Catherine Francois, Sandrine Castelain, Francois Helle – 2 February 2017 – The development of different cell culture models has greatly contributed to increased understanding of the hepatitis C virus (HCV) life cycle. However, it is still challenging to grow HCV clinical isolates in cell culture.
Safety and efficacy of transhepatic and transsplenic access for endovascular management of portal vein complications after liver transplantation
Joon‐Young Ohm, Gi‐Young Ko, Kyu‐Bo Sung, Dong‐Il Gwon, Heung Kyu Ko – 2 February 2017 – The purpose of this article is to evaluate and compare the safety and efficacy of endovascular management of the portal vein (PV) via percutaneous transsplenic access versus percutaneous transhepatic access in liver transplantation (LT) recipients. A total of 18 patients who underwent endovascular management of PV via percutaneous transhepatic (n = 8) and transsplenic (n = 10) access were enrolled.
Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit
Yaron Rotman, Brent A. Neuschwander‐Tetri – 2 February 2017
Phosphatase and tensin homolog–β‐catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury
Qiang Zhu, Changyong Li, Kunpeng Wang, Shi Yue, Longfeng Jiang, Michael Ke, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Feng Zhang, Ling Lu, Bibo Ke – 2 February 2017 – The phosphatase and tensin homolog (PTEN) deleted on chromosome 10 plays an important role in regulating T cell activation during inflammatory response. Activation of β‐catenin is crucial for maintaining immune homeostasis.
Noninvasive assessment of varices needing treatment in patients with advanced chronic liver disease: No one should be left behind
Edoardo G. Giannini, Vincenzo Savarino – 31 January 2017
The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells
Marina Vilaseca, Héctor García‐Calderó, Erica Lafoz, Oihane García‐Irigoyen, Matías A. Avila, Joan Carles Reverter, Jaume Bosch, Virginia Hernández‐Gea, Jordi Gracia‐Sancho, Joan Carles García‐Pagán – 31 January 2017 – In cirrhosis, increased intrahepatic vascular resistance (IHVR) is the primary factor for portal hypertension (PH) development. Hepatic stellate cells (HSCs) play a major role increasing IHVR because, when activated, they are contractile and promote fibrogenesis.
A novel immune function biomarker identifies patients at risk of clinical events early following liver transplantation
Siddharth Sood, Craig Haifer, Lijia Yu, Julie Pavlovic, Leonid Churilov, Paul J. Gow, Robert M. Jones, Peter W. Angus, Kumar Visvanathan, Adam G. Testro – 30 January 2017 – Balancing immunosuppression after liver transplant is difficult, with clinical events common. We investigate whether a novel immune biomarker based on a laboratory platform with widespread availability that measures interferon γ (IFNγ) after stimulation with a lyophilized ball containing an adaptive and innate immune stimulant can predict events following transplantation.
Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2–dependent angiogenesis in mice
Alex N. Gordon‐Weeks, Su Y. Lim, Arseniy E. Yuzhalin, Keaton Jones, Bostjan Markelc, K. Jin Kim, Jon N. Buzzelli, Emmanouil Fokas, Yunhong Cao, Sean Smart, Ruth Muschel – 30 January 2017 – Hepatic metastases are amenable to ablation; however, many patients are not suitable candidates for such therapy and recurrence is common. The tumor microenvironment is known to be essential for metastatic growth, yet identification of plausible targets for cancer therapy in the microenvironment has proven elusive.