18 November 2016

Tatiana Kisseleva – 18 November 2016 – Liver fibrosis results from chronic liver injury of different etiologies. It is characterized by dysregulation of physiological remodeling, activation of myofibroblasts, and formation of a fibrous scar. Myofibroblasts develop contractile functions and secrete the extracellular matrix proteins that form this fibrous scar. Myofibroblasts are not present in the normal liver but activate and proliferate in response to injury and inflammation.

Tatehiro Kagawa, Yukihiko Adachi, Naoaki Hashimoto, Hiroshi Mitsui, Tomohiko Ohashi, Masashi Yoneda, Izumi Hasegawa, Shunji Hirose, Kota Tsuruya, Kazuya Anzai, Tetsuya Mine – 18 November 2016

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, for the US Acute Liver Failure Study Group – 18 November 2016 – Acetaminophen (APAP)‐induced acute liver failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Serum liver‐type fatty acid binding protein (FABP1) early (day 1) or late (day 3‐5) levels are associated with 21‐day mortality in the absence of liver transplant.

Abhisek Mitra, Jun Yan, Xueqing Xia, Shouhao Zhou, Jian Chen, Lopa Mishra, Shulin Li – 18 November 2016 – Hepatocellular carcinoma (HCC) is the second‐leading cause of cancer‐related deaths worldwide with a poor survival rate. As many as 40% of HCCs are clonal, with alteration of key tumor‐suppressor pathways in stem cells as the primary cause of HCC initiation. However, mechanisms that generate metastatic stem cells in preneoplastic liver tissue are not well understood.

Sujit K. Mohanty, Bryan Donnelly, Inna Lobeck, Ashley Walther, Phylicia Dupree, Abigail Coots, Jaroslaw Meller, Monica McNeal, Karol Sestak, Greg Tiao – 17 November 2016 – Biliary atresia (BA) is a neonatal obstructive cholangiopathy that progresses to end‐stage liver disease, often requiring transplantation. The murine model of BA, employing rhesus rotavirus (RRV), parallels human disease and has been used to elucidate mechanistic aspects of a virus induced biliary cholangiopathy.

Melanie Tran, Li Wang – 17 November 2016

Gro Askgaard, David A. Leon, Mette S. Kjær, Thomas Deleuran, Thomas A. Gerds, Janne S. Tolstrup – 16 November 2016 – Alcoholic liver cirrhosis is usually preceded by many years of heavy drinking, in which cessation in drinking could prevent the disease. Alcohol problems are not consistently managed in hospital patients. We followed all Danish patients with an initial hospital contact with alcohol problems (intoxication, harmful use, or dependence) during 1998‐2002 for alcoholic liver cirrhosis development (n = 36,044).

This lecture will provide a vision for the global elimination of hepatitis B (HBV) and strategies to reach that goal by examining the burden of hepatitis B infection and the disparity in prevalence across different parts of the world. Programs preventing hepatitis B infection, available treatment options in chronic hepatitis B, their limitations and novel therapies will also be discussed.Anna S. Lok

This program will provide trainees and practitioners with a careful review of highly impactful and clinically relevant papers in the management of alcoholic liver disease and NAFLD. Learn the caveats associated with the design, application and final message of key clinical studies, and identify the areas of that need further study. A special focus on emerging trends in the field and how these may impact the clinical management of alcoholic liver disease and BAFLD in coming years will be discussed.Philippe Mathurin Brent A.