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Marco Laudo, Matteo Ravaioli, Gaetano Manna, Giorgia Comai, Matteo Cescon, Massimo Gaudio, Valentina Bertuzzo, Chiara Zanfi, Alessandro Cucchetti, Antonio Daniele Pinna – 24 November 2016

Disability in patients with end‐stage liver disease: Results from the functional assessment in liver transplantation study

Mariya L. Samoylova, Kenneth E. Covinsky, Marta Haftek, Selena Kuo, John P. Roberts, Jennifer C. Lai – 24 November 2016 – Cirrhosis leads to sarcopenia and functional decline that can severely impact one's ability to function at home and in society. Self‐reported disability scales to quantify disability—Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL)—are validated to predict mortality in older adults.

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

M. Pilar Valdecantos, Virginia Pardo, Laura Ruiz, Luis Castro‐Sánchez, Borja Lanzón, Elisa Fernández‐Millán, Carmelo García‐Monzón, Ana I. Arroba, Águeda González‐Rodríguez, Fernando Escrivá, Carmen Álvarez, Francisco J. Rupérez, Coral Barbas, Anish Konkar, Jacqui Naylor, David Hornigold, Ana Dos Santos, Maria Bednarek, Joseph Grimsby, Cristina M. Rondinone, Ángela M.

Bariatric surgery for nonalcoholic steatohepatitis: A clinical and cost‐effectiveness analysis

Matthew J. Klebanoff, Kathleen E. Corey, Jagpreet Chhatwal, Lee M. Kaplan, Raymond T. Chung, Chin Hur – 23 November 2016 – Nonalcoholic steatohepatitis (NASH) affects 2%‐3% of the US population and is expected to become the leading indication for liver transplantation in the next decade. Bariatric surgery may be an effective but expensive treatment for NASH. Using a state‐transition model, our analysis assessed the effectiveness and cost‐effectiveness of surgery to manage NASH.

Low‐Dose Lipopolysaccharide Causes Biliary Injury by Blood Biliary Barrier Impairment in a Rat Hepatic Ischemia/Reperfusion Model

Janske Reiling, Kim R. Bridle, Marion Gijbels, Frank G. Schaap, Lesley Jaskowski, Nishreen Santrampurwala, Laurence J. Britton, Catherine M. Campbell, Steven W. M. Olde Damink, Darrell H. G. Crawford, Cornelius H. C. Dejong, Jonathan Fawcett – 23 November 2016 – This study explored whether bacterial endotoxins, in the form of lipopolysaccharides (LPS), could have an injurious effect on the biliary tract in conjunction with ischemia.

Vascular complications in living donor liver transplantation at a high‐volume center: Evolving protocols and trends observed over 10 years

Shiraz Ahmad Rather, Mohammed A. Nayeem, Shaleen Agarwal, Neerav Goyal, Subash Gupta – 23 November 2016 – Vascular complications continue to have a devastating effect on liver transplantation recipients, even though their nature, incidence, and outcome might have actually changed with increasing experience and proficiency in high‐volume centers. The aim of this study was to analyze the trends observed in vascular complications with changing protocols in adult and pediatric living donor liver transplantation over 10 years in 2 time frames in terms of nature, incidence, and outcome.

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