Sequencing of hepatitis C virus for detection of resistance to direct‐acting antiviral therapy: A systematic review

Sofia R. Bartlett, Jason Grebely, Auda A. Eltahla, Jacqueline D. Reeves, Anita Y.M. Howe, Veronica Miller, Francesca Ceccherini‐Silberstein, Rowena A. Bull, Mark W. Douglas, Gregory J. Dore, Patrick Harrington, Andrew R. Lloyd, Brendan Jacka, Gail V. Matthews, Gary P. Wang, Jean‐Michel Pawlotsky, Jordan J. Feld, Janke Schinkel, Federico Garcia, Johan Lennerstrand, Tanya L. Applegate – 22 May 2017 – The significance of the clinical impact of direct‐acting antiviral (DAA) resistance‐associated substitutions (RASs) in hepatitis C virus (HCV) on treatment failure is unclear.

Dropout rate from the liver transplant waiting list because of hepatocellular carcinoma progression in hepatitis C virus–infected patients treated with direct‐acting antivirals

Alberto Zanetto, Sarah Shalaby, Alessandro Vitale, Claudia Mescoli, Alberto Ferrarese, Martina Gambato, Enrica Franceschet, Giacomo Germani, Marco Senzolo, Antonietta Romano, Paolo Angeli, Massimo Rugge, Fabio Farinati, Daniel M. Forton, Umberto Cillo, Patrizia Burra, Francesco Paolo Russo – 22 May 2017 – Concerns about an increased hepatocellular carcinoma (HCC) recurrence rate following direct‐acting antiviral (DAA) therapy in patients with cirrhosis with a prior complete oncological response have been raised.

Loss of L‐selectin‐guided CD8+, but not CD4+, cells protects against ischemia reperfusion injury in a steatotic liver

Vasantha L. Kolachala, Sirish Palle, Ming Shen, Alayna Feng, Dmitry Shayakhmetov, Nitika A. Gupta – 20 May 2017 – Steatotic liver responds with increased hepatocellular injury when exposed to an ischemic‐reperfusion insult. Increasing evidence supports the role of immune cells as key mediators of this injury in a normal (lean) state, but data about their role in a steatotic liver are practically nonexistent. The objective of the current study was to delineate the contribution of specific phenotypes of T cells and adhesion molecules in exacerbated cell death in steatotic liver injury.

Subscribe to