The 24‐hour normothermic machine perfusion of discarded human liver grafts

Thomas Vogel, Jens G. Brockmann, Alberto Quaglia, Alireza Morovat, Wayel Jassem, Nigel D. Heaton, Constantin C. Coussios, Peter J. Friend – 3 November 2016 – Donor organ shortage necessitates use of less than optimal donor allografts for transplantation. The current cold storage preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation (NMP) of liver allografts. In this study, we analyze discarded human liver grafts that underwent NMP for the extended period of 24 hours.

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

Sarmistha Mukherjee, Karthikeyani Chellappa, Andrea Moffitt, Joan Ndungu, Ryan W. Dellinger, James G. Davis, Beamon Agarwal, Joseph A. Baur – 3 November 2016 – The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part due to metabolic competition for precursors.

Ligation and cut as a method for bile duct division in living donor right hepatectomy

Seong Hoon Kim, Eung Chang Lee, Seung Duk Lee, Sang Jae Park – 3 November 2016 – The importance of bile duct division cannot be overemphasized in living donor surgery. Ligation and cut (LC) as a method for bile duct division in living donor right hepatectomy (LDRH) has never been reported. The purpose of this study was to introduce the LC method of bile duct division in LDRH.

Yes‐associated protein/TEA domain family member and hepatocyte nuclear factor 4‐alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice

Wang‐Yu Cai, Ling‐Yun Lin, Han Hao, Sai‐Man Zhang, Fei Ma, Xin‐Xin Hong, Hui Zhang, Qing‐Feng Liu, Guo‐Dong Ye, Guang‐Bin Sun, Yun‐Jia Liu, Sheng‐Nan Li, Yuan‐Yuan Xie, Jian‐Chun Cai, Bo‐An Li – 3 November 2016 – Great progress has been achieved in the study of Hippo signaling in regulating tumorigenesis; however, the downstream molecular events that mediate this process have not been completely defined. Moreover, regulation of Hippo signaling during tumorigenesis in hepatocellular carcinoma (HCC) remains largely unknown.

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