Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

Sarmistha Mukherjee, Karthikeyani Chellappa, Andrea Moffitt, Joan Ndungu, Ryan W. Dellinger, James G. Davis, Beamon Agarwal, Joseph A. Baur – 3 November 2016 – The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part due to metabolic competition for precursors.

The 24‐hour normothermic machine perfusion of discarded human liver grafts

Thomas Vogel, Jens G. Brockmann, Alberto Quaglia, Alireza Morovat, Wayel Jassem, Nigel D. Heaton, Constantin C. Coussios, Peter J. Friend – 3 November 2016 – Donor organ shortage necessitates use of less than optimal donor allografts for transplantation. The current cold storage preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation (NMP) of liver allografts. In this study, we analyze discarded human liver grafts that underwent NMP for the extended period of 24 hours.

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