3 March 2016

Abhishek Chauhan, David H. Adams, Steve P. Watson, Patricia F. Lalor – 2 March 2016 – Growing lines of evidence recognize that platelets play a central role in liver homeostasis and pathobiology. Platelets have important roles at every stage during the continuum of liver injury and healing. These cells contribute to the initiation of liver inflammation by promoting leukocyte recruitment through sinusoidal endothelium.

Marcus R. Pereira, Anne‐Catrin Uhlemann – 2 March 2016

Domitille Erard‐Poinsot, Olivier Guillaud, Valérie Hervieu, Elsa Thimonier, Mélanie Vallin, Christine Chambon‐Augoyard, Olivier Boillot, Jean‐Yves Scoazec, Jérôme Dumortier – 1 March 2016 – Alcoholic liver disease (ALD) is a major indication for liver transplantation (LT), but up to 20% of patients experience severe alcoholic relapse. The aims of this study were to evaluate the impact of severe alcoholic relapse on the graft (based on histological examination) and to identify predictive factors associated with recurrent alcoholic cirrhosis (RAC).

Leila Kia, Michael J. Cuttica, Amy Yang, Erica N. Donnan, Maureen Whitsett, Ajay Singhvi, Alexander Lemmer, Josh Levitsky – 1 March 2016 – Although pulmonary function tests (PFTs) are routinely performed in patients during the evaluation period before liver transplantation (LT), their utility in predicting post‐LT mortality and morbidity outcomes is not known. The aim of this study was to determine the impact of obstructive and/or restrictive lung disease on post‐LT outcomes. We conducted a retrospective analysis of patients who had pre‐LT PFTs and underwent a subsequent LT (2007‐2013).

Anna K. Baumann, Jerome Schlue, Fatih Noyan, Matthias Hardtke‐Wolenski, Frank Lehner, Hannelore Barg‐Hock, Juergen Klempnauer, Michael P. Manns, Richard Taubert, Elmar Jaeckel – 1 March 2016 – Subclinical rejection (SCR) is a common event in protocol biopsies after liver transplantation (LT). So far the interpretation of the underlying histological changes and clinical significance is limited. Previous studies were restricted to SCR manifestations within the first weeks after transplantation with limited follow‐up.

Peter Eddowes, Magali Sasso, Celine Fournier, Raj Vuppalanchi, Philip Newsome – 29 February 2016

Tae Hoon Lee, Vikram Rangan, Hicham Khallafi – 29 February 2016 – Sphenoid sinus metastasis from hepatocellular carcinoma (HCC) has been reported only rarely. We present a case of solitary sphenoid sinus metastasis of a 2.7 × 2.3 cm single HCC lesion. (Hepatology 2016;63:2050‐2053)

Qi Gong, Zhimin Hu, Feifei Zhang, Aoyuan Cui, Xin Chen, Haoyang Jiang, Jing Gao, Xuqing Chen, Yamei Han, Qingning Liang, Dewei Ye, Lei Shi, Y. Eugene Chin, Yu Wang, Hui Xiao, Feifan Guo, Yong Liu, Mengwei Zang, Aimin Xu, Yu Li – 29 February 2016 – Among the 22 fibroblast growth factors (FGFs), FGF21 has now emerged as a key metabolic regulator. However, the mechanism whereby FGF21 mediates its metabolic actions per se remains largely unknown.

Lorenzo Giovanni Mantovani, Paolo Angelo Cortesi, Mario Strazzabosco – 29 February 2016 – In the current context of rising health care costs and decreasing sustainability, it is becoming increasingly common to resort to decision analytical modeling and health economics evaluations. Decision analytic models are analytical tools that help decision makers to select the best choice between alternative health care interventions, taking into consideration the complexity of the disease, the socioeconomic context, and the relevant differences in outcomes.