Abhishek Chauhan, David H. Adams, Steve P. Watson, Patricia F. Lalor – 2 March 2016 – Growing lines of evidence recognize that platelets play a central role in liver homeostasis and pathobiology. Platelets have important roles at every stage during the continuum of liver injury and healing. These cells contribute to the initiation of liver inflammation by promoting leukocyte recruitment through sinusoidal endothelium.
Anna K. Baumann, Jerome Schlue, Fatih Noyan, Matthias Hardtke‐Wolenski, Frank Lehner, Hannelore Barg‐Hock, Juergen Klempnauer, Michael P. Manns, Richard Taubert, Elmar Jaeckel – 1 March 2016 – Subclinical rejection (SCR) is a common event in protocol biopsies after liver transplantation (LT). So far the interpretation of the underlying histological changes and clinical significance is limited. Previous studies were restricted to SCR manifestations within the first weeks after transplantation with limited follow‐up.
Leila Kia, Michael J. Cuttica, Amy Yang, Erica N. Donnan, Maureen Whitsett, Ajay Singhvi, Alexander Lemmer, Josh Levitsky – 1 March 2016 – Although pulmonary function tests (PFTs) are routinely performed in patients during the evaluation period before liver transplantation (LT), their utility in predicting post‐LT mortality and morbidity outcomes is not known. The aim of this study was to determine the impact of obstructive and/or restrictive lung disease on post‐LT outcomes. We conducted a retrospective analysis of patients who had pre‐LT PFTs and underwent a subsequent LT (2007‐2013).
Domitille Erard‐Poinsot, Olivier Guillaud, Valérie Hervieu, Elsa Thimonier, Mélanie Vallin, Christine Chambon‐Augoyard, Olivier Boillot, Jean‐Yves Scoazec, Jérôme Dumortier – 1 March 2016 – Alcoholic liver disease (ALD) is a major indication for liver transplantation (LT), but up to 20% of patients experience severe alcoholic relapse. The aims of this study were to evaluate the impact of severe alcoholic relapse on the graft (based on histological examination) and to identify predictive factors associated with recurrent alcoholic cirrhosis (RAC).
Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu – 29 February 2016 – Hyperhomocysteinemia (HHcy) is associated with liver diseases such as fatty liver and hepatic fibrosis; however, the underlying mechanism is still largely unknown. The current study aimed to explore the signaling pathway involved in HHcy‐induced hepatic steatosis (HS). C57BL/6 mice were fed a high‐methionine diet (HMD) for 4 and 8 weeks to establish the HHcy mouse model.
Meenakshisundaram Ananthanarayanan – 29 February 2016
Maria Eugenia Guicciardi, Gregory J. Gores – 29 February 2016
Yung‐Yi Chen, Hannah C. Jeffery, Stuart Hunter, Ricky Bhogal, Jane Birtwistle, Manjit Kaur Braitch, Sheree Roberts, Mikaela Ming, Jack Hannah, Clare Thomas, Gupse Adali, Stefan G. Hübscher, Wing‐Kin Syn, Simon Afford, Patricia F. Lalor, David H. Adams, Ye H. Oo – 29 February 2016 – Regulatory T cells (Treg) suppress T effector cell proliferation and maintain immune homeostasis. Autoimmune liver diseases persist despite high frequencies of Treg in the liver, suggesting that the local hepatic microenvironment might affect Treg stability, survival, and function.
Mary Rinella, Michael Charlton – 29 February 2016
Naoki Tanimizu, Kota Kaneko, Tohru Itoh, Norihisa Ichinohe, Masayuki Ishii, Toru Mizuguchi, Koichi Hirata, Atsushi Miyajima, Toshihiro Mitaka – 29 February 2016 – The intrahepatic bile duct (IHBD) is a highly organized tubular structure consisting of cholangiocytes, biliary epithelial cells, which drains bile produced by hepatocytes into the duodenum. Although several models have been proposed, it remains unclear how the three‐dimensional (3D) IHBD network develops during liver organogenesis.