Development and Validation of a Disease‐Specific Questionnaire to Assess Patient‐Reported Symptoms in Polycystic Liver Disease

Myrte K. Neijenhuis, Tom J.G. Gevers, Marie C. Hogan, Patrick S. Kamath, Titus F.M. Wijnands, Ralf C.P.M. van den Ouweland, Marie E. Edwards, Jeff A. Sloan, Wietske Kievit, Joost P.H. Drenth – 11 March 2016 – Treatment of polycystic liver disease (PLD) focuses on symptom improvement. Generic questionnaires lack sensitivity to capture PLD‐related symptoms, a prerequisite to determine effectiveness of therapy. We developed and validated a disease‐specific questionnaire that assesses symptoms in PLD (PLD‐Q).

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Ahmed Hassaan Qavi, Sahla Hammad, Atif I. Rana, Mohammad Salih, Najmul Hassan Shah, Faisal S. Dar, Arsalan Ahmad – 11 March 2016

An early look at the Organ Procurement and Transplantation Network explant pathology form data

Ann M. Harper, Erick Edwards, W. Kenneth Washburn, Julie Heimbach – 11 March 2016 – In April 2012, the Organ Procurement and Transplantation Network (OPTN) implemented an online explant pathology form for recipients of liver transplantation who received additional wait‐list priority for their diagnosis of hepatocellular carcinoma (HCC). The purpose of the form was to standardize the data being reported to the OPTN, which had been required since 2002 but were submitted to the OPTN in a variety of formats via facsimile.

Hedgehog regulates yes‐associated protein 1 in regenerating mouse liver

Marzena Swiderska‐Syn, Guanhua Xie, Gregory A. Michelotti, Mark L. Jewell, Richard T. Premont, Wing‐Kin Syn, Anna Mae Diehl – 11 March 2016 – Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity to change within individual liver cells, and that coordinate proliferative activity among different types of liver cells, are not well understood.

CD14 is associated with biliary stricture formation

Kilian Friedrich, Mark Smit, Maik Brune, Thomas Giese, Christian Rupp, Andreas Wannhoff, Petra Kloeters, Yvonne Leopold, Gerald Ulrich Denk, Karl Heinz Weiss, Wolfgang Stremmel, Peter Sauer, Simon Hohenester, Peter Schirmacher, Peter Schemmer, Daniel Nils Gotthardt – 11 March 2016 – The pathogenesis of intrahepatic biliary stricture formation in patients with primary sclerosing cholangitis (PSC) or after liver transplantation (LTx) remains elusive. CD14 receptor signaling is a key mediator of the innate immune system; its common genetic variant is associated with alcoholic liver disease.

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