The new liver allocation score for transplantation is validated and improved transplant survival benefit in Germany but not in the United Kingdom

Harald Schrem, Moritz Focken, Bridget Gunson, Benedikt Reichert, Darius Mirza, Hans‐Heinrich Kreipe, Desley Neil, Alexander Kaltenborn, Alon Goldis, Christian Krauth, Keith Roberts, Thomas Becker, Jürgen Klempnauer, James Neuberger – 7 March 2016 – Prognostic models for the prediction of 90‐day mortality after transplantation with pretransplant donor and recipient variables are needed to calculate transplant benefit.

Is severe progressive liver disease caused by alpha‐1‐antitrypsin deficiency more common in children or adults?

Andrew S. Chu, Kapil B. Chopra, David H. Perlmutter – 6 March 2016 – The classical form of alpha‐1‐antitrypsin deficiency (A1ATD) is known to cause liver disease in children and adults, but there is relatively little information about the risk of severe, progressive liver disease and the need for liver transplantation.

Pediatric acute liver failure in Brazil: Is living donor liver transplantation the best choice for treatment?

Ana Cristina Aoun Tannuri, Gilda Porta, Irene Kazue Miura, Maria Merces Santos, Daniel de Albuquerque Rangel Moreira, Nathassia Mancebo Avila de Rezende, Helena Thie Miyatani, Uenis Tannuri – 6 March 2016 – Acute liver failure (ALF) in children is a life‐threatening condition that often leads to urgent liver transplantation (LT). The aim of the present investigation was to describe the experience in Brazil in treating pediatric ALF, with an emphasis on the role of living donor liver transplantation (LDLT) in treating this condition.

Neonatal acute liver failure

Sarah A. Taylor, Peter F. Whitington – 6 March 2016 – Neonatal acute liver failure (NALF) is a rare disease about which there is little published data; however, NALF is an extremely important condition as it is distinct from acute liver failure seen in older children and adults. First, unlike acute liver failure in older patients, NALF can be diagnosed in an infant with cirrhosis. This is due to the fetal‐neonatal continuum of liver disease, or the principle that neonatal liver failure may be the result of a liver disease that began in utero.

Normothermic machine perfusion reduces bile duct injury and improves biliary epithelial function in rat donor livers

Sanna op den Dries, Negin Karimian, Andrie C. Westerkamp, Michael E. Sutton, Michiel Kuipers, Janneke Wiersema‐Buist, Petra J. Ottens, Jeroen Kuipers, Ben N. Giepmans, Henri G. D. Leuvenink, Ton Lisman, Robert J. Porte – 6 March 2016 – Bile duct injury may occur during liver procurement and transplantation, especially in livers from donation after circulatory death (DCD) donors. Normothermic machine perfusion (NMP) has been shown to reduce hepatic injury compared to static cold storage (SCS). However, it is unknown whether NMP provides better preservation of bile ducts.

Subscribe to