MicroRNA‐122 regulates polyploidization in the murine liver

Shu‐hao Hsu, Evan R. Delgado, P. Anthony Otero, Kun‐yu Teng, Huban Kutay, Kolin M. Meehan, Justin B. Moroney, Jappmann K. Monga, Nicholas J. Hand, Joshua R. Friedman, Kalpana Ghoshal, Andrew W. Duncan – 26 March 2016 – A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement of chromosomes. The first step of polyploidization involves cell division with failed cytokinesis.

Assessing the therapeutic potential of lab‐made hepatocytes

Milad Rezvani, Andrew A. Grimm, Holger Willenbring – 25 March 2016 – Hepatocyte transplantation has potential as a bridge or even alternative to whole‐organ liver transplantation. Because donor livers are scarce, realizing this potential requires the development of alternative cell sources. To be therapeutically effective, surrogate hepatocytes must replicate the complex function and ability to proliferate of primary human hepatocytes.

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