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Xu Yang, Xiao‐peng Tang, Yong‐hong Zhang, Kai‐zhong Luo, Yong‐fang Jiang, Hong‐yu Luo, Jian‐hua Lei, Wen‐long Wang, Ming‐ming Li, Han‐chun Chen, Shi‐lin Deng, Li‐ying Lai, Jun Liang, Min Zhang, Yi Tian, Yun Xu – 21 March 2016

Hepatic gene transfer of human aquaporin‐1 improves bile salt secretory failure in rats with estrogen‐induced cholestasis

Julieta Marrone, Leandro R. Soria, Mauro Danielli, Guillermo L. Lehmann, Maria Cecilia Larocca, Raúl A. Marinelli – 21 March 2016 – The adenoviral gene transfer of human aquaporin‐1 (hAQP1) water channels to the liver of 17α‐ethinylestradiol‐induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1‐mediated osmotic water secretion. To gain insight into the mechanisms of 17α‐ethinylestradiol cholestasis improvement, we studied the biliary output of bile salts (BS) and the functional expression of the canalicular BS export pump (BSEP; ABCB11).

DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration

Kosuke Kaji, Valentina M. Factor, Jesper B. Andersen, Marian E. Durkin, Akira Tomokuni, Jens U. Marquardt, Matthias S. Matter, Tanya Hoang, Elizabeth A. Conner, Snorri S. Thorgeirsson – 21 March 2016 – DNA methyltransferase 1 (DNMT1) is an essential regulator maintaining both epigenetic reprogramming during DNA replication and genome stability. We investigated the role of DNMT1 in the regulation of postnatal liver histogenesis under homeostasis and stress conditions.

Suppression of lethal‐7b and miR‐125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts

Yasuo Takashima, Maiko Terada, Miyako Udono, Shizuka Miura, Junpei Yamamoto, Atsushi Suzuki – 17 March 2016 – In liver development, hepatoblasts that act as hepatic stem/progenitor cells proliferate and differentiate into both hepatocytes and cholangiocytes to form liver tissues. Although numerous factors contribute to this event, little is known about the roles of microRNAs in hepatoblast proliferation and differentiation.

Lorcaserin Use in the Management of Morbid Obesity in a Pre‐Liver Transplant Patient

Julio A. Gutierrez, Carmen Landaverde, Jennifer T. Wells, Fred Poordad – 17 March 2016 – Management of obesity and decompensated cirrhosis in those requiring liver transplantation (LT) is a challenging dilemma. Because of concerns for perioperative complications, many centers avoid transplant in those with a body mass index (BMI) greater than 40 kg/m2. Bariatric surgery is associated with increased risk attributable to complications of portal hypertension, including variceal rupture. Therefore, weight loss and LT options are limited.

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