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Xu Yang, Xiao‐peng Tang, Yong‐hong Zhang, Kai‐zhong Luo, Yong‐fang Jiang, Hong‐yu Luo, Jian‐hua Lei, Wen‐long Wang, Ming‐ming Li, Han‐chun Chen, Shi‐lin Deng, Li‐ying Lai, Jun Liang, Min Zhang, Yi Tian, Yun Xu – 21 March 2016

Hepatic gene transfer of human aquaporin‐1 improves bile salt secretory failure in rats with estrogen‐induced cholestasis

Julieta Marrone, Leandro R. Soria, Mauro Danielli, Guillermo L. Lehmann, Maria Cecilia Larocca, Raúl A. Marinelli – 21 March 2016 – The adenoviral gene transfer of human aquaporin‐1 (hAQP1) water channels to the liver of 17α‐ethinylestradiol‐induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1‐mediated osmotic water secretion. To gain insight into the mechanisms of 17α‐ethinylestradiol cholestasis improvement, we studied the biliary output of bile salts (BS) and the functional expression of the canalicular BS export pump (BSEP; ABCB11).

DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration

Kosuke Kaji, Valentina M. Factor, Jesper B. Andersen, Marian E. Durkin, Akira Tomokuni, Jens U. Marquardt, Matthias S. Matter, Tanya Hoang, Elizabeth A. Conner, Snorri S. Thorgeirsson – 21 March 2016 – DNA methyltransferase 1 (DNMT1) is an essential regulator maintaining both epigenetic reprogramming during DNA replication and genome stability. We investigated the role of DNMT1 in the regulation of postnatal liver histogenesis under homeostasis and stress conditions.

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