Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Alan Ka‐Lun Kai, Lo Kong Chan, Regina Cheuk‐Lam Lo, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Jack Chun‐Ming Wong, Irene Oi‐Lin Ng – 28 March 2016 – Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of hepatocellular carcinoma (HCC) metastasis.

MicroRNA‐122 regulates polyploidization in the murine liver

Shu‐hao Hsu, Evan R. Delgado, P. Anthony Otero, Kun‐yu Teng, Huban Kutay, Kolin M. Meehan, Justin B. Moroney, Jappmann K. Monga, Nicholas J. Hand, Joshua R. Friedman, Kalpana Ghoshal, Andrew W. Duncan – 26 March 2016 – A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement of chromosomes. The first step of polyploidization involves cell division with failed cytokinesis.

Hepatitis C Disease Burden in the United States in the era of oral direct‐acting antivirals

Jagpreet Chhatwal, Xiaojie Wang, Turgay Ayer, Mina Kabiri, Raymond T. Chung, Chin Hur, Julie M. Donohue, Mark S. Roberts, Fasiha Kanwal – 25 March 2016 – Oral direct‐acting antivirals (DAAs) represent a major advance in hepatitis C virus (HCV) treatment. Along with recent updates in HCV screening policy and expansions in insurance coverage, treatment demand in the United States is changing rapidly. Our objective was to project the characteristics and number of people needing antiviral treatment and HCV‐associated disease burden in the era of oral DAAs.

Retracted: Immunoglobulin G4+ B‐cell receptor clones distinguish immunoglobulin G 4‐related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies

Marieke E. Doorenspleet, Lowiek M. Hubers, Emma L. Culver, Lucas J. Maillette de Buy Wenniger, Paul L. Klarenbeek, Roger W. Chapman, Frank Baas, Stan F. van de Graaf, Joanne Verheij, Thomas M. van Gulik, Eleanor Barnes, Ulrich Beuers, Niek de Vries – 25 March 2016 – Immunoglobulin G4 (IgG4)‐related disease (IgG4‐RD) of the biliary tree and pancreas is difficult to distinguish from sclerosing cholangitis and biliary/pancreatic malignancies (CA). An accurate noninvasive test for diagnosis and monitoring of disease activity is lacking.

Metallothionein‐1G facilitates sorafenib resistance through inhibition of ferroptosis

Xiaofang Sun, Xiaohua Niu, Ruochan Chen, Wenyin He, De Chen, Rui Kang, Daolin Tang – 25 March 2016 – Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide and currently has the fastest rising incidence of all cancers. Sorafenib was originally identified as an inhibitor of multiple oncogenic kinases and remains the only approved systemic therapy for advanced HCC. However, acquired resistance to sorafenib has been found in HCC patients, which results in poor prognosis.

Subscribe to