Protective role of normothermic machine perfusion during reduced‐size liver transplantation in pigs

Zhi‐Bin Zhang, Wei Gao, Yuan Shi, Lei Liu, Ning Ma, Jing Chen, Zhi‐Jun Zhu – 31 March 2016 – The purpose of this study is to explore whether normothermic machine perfusion (NMP) preservation is superior to cold preservation during reduced‐size liver transplantation (RSLT) in pigs. Twenty‐four healthy Ba‐Ma mini pigs were used (aged >13 months; weight 25‐35 kg; regardless of sex). The animals were randomized into 2 groups.

Development of a normothermic extracorporeal liver perfusion system toward improving viability and function of human extended criteria donor livers

Babak Banan, Rao Watson, Min Xu, Yiing Lin, William Chapman – 30 March 2016 – Donor organ shortages have led to an increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic extracorporeal liver perfusion (NELP) has been proposed as a superior preservation method to reduce ischemia/reperfusion injury (IRI), precondition suboptimal grafts, and treat ECD livers so that they can be successfully used for transplantation. The aim of this study was to investigate the beneficial effects of a modified NELP circuit on discarded human livers.

Longterm results of liver transplantation from donation after circulatory death

Joris J. Blok, Olivier Detry, Hein Putter, Xavier Rogiers, Robert J. Porte, Bart van Hoek, Jacques Pirenne, Herold J. Metselaar, Jan P. Lerut, Dirk K. Ysebaert, Valerio Lucidi, Roberto I. Troisi, Undine Samuel, A. Claire den Dulk, Jan Ringers, Andries E. Braat, for the Eurotransplant Liver Intestine Advisory Committee – 30 March 2016 – Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic‐type biliary lesions.

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