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Joseph Ralph Kallini, Ahmed Gabr, Laura Kulik, Daniel Ganger, Robert Lewandowski, Bartley Thornburg, Riad Salem – 28 March 2016

Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Alan Ka‐Lun Kai, Lo Kong Chan, Regina Cheuk‐Lam Lo, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Jack Chun‐Ming Wong, Irene Oi‐Lin Ng – 28 March 2016 – Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of hepatocellular carcinoma (HCC) metastasis.

MicroRNA‐122 regulates polyploidization in the murine liver

Shu‐hao Hsu, Evan R. Delgado, P. Anthony Otero, Kun‐yu Teng, Huban Kutay, Kolin M. Meehan, Justin B. Moroney, Jappmann K. Monga, Nicholas J. Hand, Joshua R. Friedman, Kalpana Ghoshal, Andrew W. Duncan – 26 March 2016 – A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement of chromosomes. The first step of polyploidization involves cell division with failed cytokinesis.

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