Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish

Xiao Zhao, Kristin Lorent, Benjamin J. Wilkins, Dylan M. Marchione, Kevin Gillespie, Orith Waisbourd‐Zinman, Juhoon So, Kyung Ah Koo, Donghun Shin, John R. Porter, Rebecca G. Wells, Ian Blair, Michael Pack – 21 April 2016 – Biliatresone is an electrophilic isoflavone isolated from Dysphania species plants that has been causatively linked to naturally occurring outbreaks of a biliary atresia (BA)‐like disease in livestock. Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHCs) in zebrafish larvae.

Genetic lineage tracing analysis of the cell of origin of hepatotoxin‐induced liver tumors in mice

Soona Shin, Kirk J. Wangensteen, Monica Teta‐Bissett, Yue J. Wang, Elham Mosleh‐Shirazi, Elizabeth L. Buza, Linda E. Greenbaum, Klaus H. Kaestner – 21 April 2016 – The expression of biliary/progenitor markers by hepatocellular carcinoma (HCC) is often associated with poor prognosis and stem cell‐like behaviors of tumor cells. Hepatocellular adenomas (HCAs) also often express biliary/progenitor markers and frequently act as precursor lesions for HCC. However, the cell of origin of HCA and HCC that expresses these markers remains unclear.

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