Intention‐to‐treat analysis of percutaneous endovascular treatment of hepatic artery stenosis after orthotopic liver transplantation

Muthukumarassamy Rajakannu, Sameh Awad, Oriana Ciacio, Gabriella Pittau, René Adam, Antonio Sa Cunha, Denis Castaing, Didier Samuel, Maïté Lewin, Daniel Cherqui, Eric Vibert – 20 April 2016 – Hepatic artery stenosis (HAS) is a rare complication of orthotopic liver transplantation (LT). HAS could evolve into complete thrombosis and lead to graft loss, incurring significant morbidity and mortality.

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐catenin

Junyan Tao, Emily Xu, Yifei Zhao, Sucha Singh, Xiaolei Li, Gabrielle Couchy, Xin Chen, Jessica Zucman‐Rossi, Maria Chikina, Satdarshan P.S. Monga – 20 April 2016 – Hepatocellular cancer (HCC) remains a significant therapeutic challenge due to its poorly understood molecular basis. In the current study, we investigated two independent cohorts of 249 and 194 HCC cases for any combinatorial molecular aberrations. Specifically we assessed for simultaneous HMET expression or hMet activation and catenin β1 gene (CTNNB1) mutations to address any concomitant Met and Wnt signaling.

Pediatric liver transplantation: Personal perspectives on historical achievements and future challenges

Jean‐Bernard Otte – 20 April 2016 – This review presents the author's personal perspective and contributions to the first steps, the development, the current status, and the remaining issues of pediatric liver transplantation (LT). Innumerable children around the world who have undergone LT have reached adulthood. The techniques have reached maturity. As shown by my own group's experience, grafts donated by living donors might provide the best short‐term and longterm results. Debate persists about the optimal immunosuppression (IS), although the place of tacrolimus remains unchallenged.

Randomized, open‐label phase 2 study comparing frontline dovitinib versus sorafenib in patients with advanced hepatocellular carcinoma

Ann‐Lii Cheng, Sumitra Thongprasert, Ho Yeong Lim, Wattana Sukeepaisarnjaroen, Tsai‐Shen Yang, Cheng‐Chung Wu, Yee Chao, Stephen L. Chan, Masatoshi Kudo, Masafumi Ikeda, Yoon‐Koo Kang, Hongming Pan, Kazushi Numata, Guohong Han, Binaifer Balsara, Yong Zhang, Ana‐Marie Rodriguez, Yi Zhang, Yongyu Wang, Ronnie T. P.

Serum Levels of Hepatitis B Surface Antigen and DNA Can Predict Inactive Carriers With Low Risk of Disease Progression

Jessica Liu, Hwai‐I Yang, Mei‐Hsuan Lee, Chin‐Lan Jen, Richard Batrla‐Utermann, Sheng‐Nan Lu, Li‐Yu Wang, San‐Lin You, Chien‐Jen Chen – 15 April 2016 – Serum levels of hepatitis B virus (HBV) DNA (≤2000 IU/mL) and hepatitis B surface antigen (HBsAg) (<1000 IU/mL) have been shown to distinguish inactive carriers with high accuracy. The goal of this study was to validate the predictability of one‐time measurement of quantitative HBsAg and HBV DNA levels for inactive carrier status and chronic hepatitis B (CHB) progression in a community‐based cohort.

Liver transplantation in the United Kingdom

James Neuberger – 15 April 2016 – Liver transplantation (LT) services in the United Kingdom are provided by 7 designated transplant centers for a population of approximately 64 million. The number of deceased organ donors has grown, and in 2014‐2015 it was 1282 (570 donation after circulatory death and 772 donation after brain death). Donor risk is increasing. In 2014‐2015, there were 829 LTs from deceased and 38 from living donors. The common causes for transplantation are liver cell cancer, viral hepatitis, and alcohol‐related liver disease.

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