Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish

Xiao Zhao, Kristin Lorent, Benjamin J. Wilkins, Dylan M. Marchione, Kevin Gillespie, Orith Waisbourd‐Zinman, Juhoon So, Kyung Ah Koo, Donghun Shin, John R. Porter, Rebecca G. Wells, Ian Blair, Michael Pack – 21 April 2016 – Biliatresone is an electrophilic isoflavone isolated from Dysphania species plants that has been causatively linked to naturally occurring outbreaks of a biliary atresia (BA)‐like disease in livestock. Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHCs) in zebrafish larvae.

Intention‐to‐treat analysis of percutaneous endovascular treatment of hepatic artery stenosis after orthotopic liver transplantation

Muthukumarassamy Rajakannu, Sameh Awad, Oriana Ciacio, Gabriella Pittau, René Adam, Antonio Sa Cunha, Denis Castaing, Didier Samuel, Maïté Lewin, Daniel Cherqui, Eric Vibert – 20 April 2016 – Hepatic artery stenosis (HAS) is a rare complication of orthotopic liver transplantation (LT). HAS could evolve into complete thrombosis and lead to graft loss, incurring significant morbidity and mortality.

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