| AASLD

Intention‐to‐treat survival analysis of hepatitis C virus/human immunodeficiency virus coinfected liver transplant: Is it the waiting list?

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Juan J. Araiz, M. Trinidad Serrano, Francisco A. García‐Gil, Elena M. Lacruz, Sara Lorente, José I. Sánchez, Miguel A. Suarez – 26 April 2016 – In human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients, the accelerated severity of liver disease, associated comorbidities, and mortality on the waiting list could change the possibility and results of liver transplantation (LT). Intention‐to‐treat survival analysis (ITTA) can accurately estimate the applicability and efficacy of LT.

Hepatitis C genotype 4R resistance‐associated polymorphisms: The achilles heel of the nonstructural 5A inhibitors?

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Philippe Halfon, Sofiane Mohamed, Guillaume Penaranda, Hacène Khiri, Laurent Chiche, Carine Nicolas, Armand Abergel – 26 April 2016

Successful antiviral treatment of chronic hepatitis C leads to a rapid decline of liver stiffness without an early effect on spleen stiffness

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Wim Verlinden, Sven Francque, Peter Michielsen, Thomas Vanwolleghem – 26 April 2016

ISSN

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26 April 2016

Cell‐specific overactivation of nuclear erythroid 2 p45‐related factor 2–mediated gene expression in myeloid cells decreases hepatic ischemia/reperfusion injury

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Lung‐Yi Lee, Calvin Harberg, Kristina A. Matkowskyj, Shelly Cook, Drew Roenneburg, Sabine Werner, Delinda A. Johnson, Jeffrey A. Johnson, David P. Foley – 26 April 2016 – Hepatic ischemia/reperfusion injury (IRI) is an unavoidable consequence of liver transplantation that can lead to postoperative hepatic dysfunction. Myeloid cells that include Kupffer cells, monocytes, and neutrophils contribute to the inflammatory response and cellular injury observed during hepatic IRI.

Meeting Notices

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26 April 2016

Real‐world effectiveness of ledipasvir/sofosbuvir in 4,365 treatment‐naive, genotype 1 hepatitis C‐infected patients

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Lisa I. Backus, Pamela S. Belperio, Troy A. Shahoumian, Timothy P. Loomis, Larry A. Mole – 26 April 2016 – Real‐world effectiveness data are needed to inform hepatitis C virus (HCV) treatment decisions. The uptake of ledipasvir/sofosbuvir (LDV/SOF) regimens across health care settings has been rapid, but variations often occur in clinical practice. The aim of this study was to assess sustained virologic response (SVR) of LDV/SOF±ribavirin (RBV) in routine medical practice.

The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor‐β1 biliary secretion in mice

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Nan Wu, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Julie Venter, Holly Standeford, Paolo Onori, Marco Marzioni, Domenico Alvaro, Antonio Franchitto, Eugenio Gaudio, Shannon Glaser, Gianfranco Alpini – 26 April 2016 – The secretin/secretin receptor (SR) axis is up‐regulated by proliferating cholangiocytes during cholestasis. Secretin stimulates biliary proliferation by down‐regulation of let‐7a and subsequent up‐regulation of the growth‐promoting factor, nerve growth factor (NGF).