Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma
Alan Ka‐Lun Kai, Lo Kong Chan, Regina Cheuk‐Lam Lo, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Jack Chun‐Ming Wong, Irene Oi‐Lin Ng – 28 March 2016 – Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of hepatocellular carcinoma (HCC) metastasis.