Novel strategy to decrease reperfusion injuries and improve function of cold‐preserved livers using normothermic ex vivo liver perfusion machine

Babak Banan, Zhenyu Xiao, Rao Watson, Min Xu, Jianluo Jia, Gundumi A. Upadhya, Thalachallour Mohanakumar, Yiing Lin, William Chapman – 5 October 2015 – Normothermic extracorporeal liver perfusion (NELP) can decrease ischemia/reperfusion injury to the greatest degree when cold ischemia time is minimized. Warm perfusion of cold‐stored livers results in hepatocellular damage, sinusoidal endothelial cell (SEC) dysfunction, and Kupffer cell activation. However, the logistics of organ procurement mandates a period of cold preservation before NELP.

Biliary strictures and recurrence after liver transplantation for primary sclerosing cholangitis: A retrospective multicenter analysis

Tatiana Hildebrand, Nadine Pannicke, Alexander Dechene, Daniel N. Gotthardt, Gabriele Kirchner, Florian P. Reiter, Martina Sterneck, Kerstin Herzer, Henrike Lenzen, Christian Rupp, Hannelore Barg‐Hock, Philipp Leuw, Andreas Teufel, Vincent Zimmer, Frank Lammert, Christoph Sarrazin, Ulrich Spengler, Christian Rust, Michael P. Manns, Christian P. Strassburg, Christoph Schramm, Tobias J.

Novel population‐based study finding higher than reported hepatocellular carcinoma incidence suggests an updated approach is needed

Thai P. Hong, Paul Gow, Michael Fink, Anouk Dev, Stuart Roberts, Amanda Nicoll, John Lubel, Ian Kronborg, Niranjan Arachchi, Marno Ryan, William Kemp, Virginia Knight, Helen Farrugia, Vicky Thursfield, Paul Desmond, Alexander J. Thompson, Sally Bell – 5 October 2015 – Hepatocellular carcinoma (HCC) incidence is rising rapidly in many developed countries.

Association between nucleos(t)ide analog and tumor recurrence in hepatitis B virus–related hepatocellular carcinoma after radiofrequency ablation

Teng‐Yu Lee, Jaw‐Town Lin, Yi‐Siou Zeng, Yi‐Ju Chen, Ming‐Shiang Wu, Chun‐Ying Wu – 1 October 2015 – Radiofrequency ablation (RFA) is the best choice for curative treatment of hepatocellular carcinoma (HCC) cases not suitable for surgical intervention, but efforts should be made to reduce the risk of tumor recurrence. We aimed to investigate the association between nucleos(t)ide analog (NA) therapy for hepatitis B virus (HBV) and the risk of HCC recurrence post‐RFA.

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

Shadi Abu‐Hayyeh, Caroline Ovadia, TinaMarie Lieu, Dane D. Jensen, Jenny Chambers, Peter H. Dixon, Anita Lövgren‐Sandblom, Ruth Bolier, Dagmar Tolenaars, Andreas E. Kremer, Argyro Syngelaki, Muna Noori, David Williams, Jose J.G. Marin, Maria J. Monte, Kypros H. Nicolaides, Ulrich Beuers, Ronald Oude‐Elferink, Paul T. Seed, Lucy Chappell, Hanns‐Ulrich Marschall, Nigel W.

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