Development of a normothermic extracorporeal liver perfusion system toward improving viability and function of human extended criteria donor livers
Babak Banan, Rao Watson, Min Xu, Yiing Lin, William Chapman – 30 March 2016 – Donor organ shortages have led to an increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic extracorporeal liver perfusion (NELP) has been proposed as a superior preservation method to reduce ischemia/reperfusion injury (IRI), precondition suboptimal grafts, and treat ECD livers so that they can be successfully used for transplantation. The aim of this study was to investigate the beneficial effects of a modified NELP circuit on discarded human livers.