Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish

Xiao Zhao, Kristin Lorent, Benjamin J. Wilkins, Dylan M. Marchione, Kevin Gillespie, Orith Waisbourd‐Zinman, Juhoon So, Kyung Ah Koo, Donghun Shin, John R. Porter, Rebecca G. Wells, Ian Blair, Michael Pack – 21 April 2016 – Biliatresone is an electrophilic isoflavone isolated from Dysphania species plants that has been causatively linked to naturally occurring outbreaks of a biliary atresia (BA)‐like disease in livestock. Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHCs) in zebrafish larvae.

Genetic lineage tracing analysis of the cell of origin of hepatotoxin‐induced liver tumors in mice

Soona Shin, Kirk J. Wangensteen, Monica Teta‐Bissett, Yue J. Wang, Elham Mosleh‐Shirazi, Elizabeth L. Buza, Linda E. Greenbaum, Klaus H. Kaestner – 21 April 2016 – The expression of biliary/progenitor markers by hepatocellular carcinoma (HCC) is often associated with poor prognosis and stem cell‐like behaviors of tumor cells. Hepatocellular adenomas (HCAs) also often express biliary/progenitor markers and frequently act as precursor lesions for HCC. However, the cell of origin of HCA and HCC that expresses these markers remains unclear.

Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats

Shinya Okumura, Takumi Teratani, Yasuhiro Fujimoto, Xiangdong Zhao, Tatsuaki Tsuruyama, Yuki Masano, Naoya Kasahara, Taku Iida, Shintaro Yagi, Tadahiro Uemura, Toshimi Kaido, Shinji Uemoto – 21 April 2016 – Polyamines are essential for cell growth and differentiation. They play important roles in protection from liver damage and promotion of liver regeneration. However, little is known about the effect of oral exogenous polyamine administration on liver damage and regeneration.

Pediatric liver transplantation: Personal perspectives on historical achievements and future challenges

Jean‐Bernard Otte – 20 April 2016 – This review presents the author's personal perspective and contributions to the first steps, the development, the current status, and the remaining issues of pediatric liver transplantation (LT). Innumerable children around the world who have undergone LT have reached adulthood. The techniques have reached maturity. As shown by my own group's experience, grafts donated by living donors might provide the best short‐term and longterm results. Debate persists about the optimal immunosuppression (IS), although the place of tacrolimus remains unchallenged.

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