Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

Yun‐Yong Park, Bo Hwa Sohn, Randy L. Johnson, Myoung‐Hee Kang, Sang Bae Kim, Jae‐Jun Shim, Lingegowda S. Mangala, Ji Hoon Kim, Jeong Eun Yoo, Cristian Rodriguez‐Aguayo, Sunila Pradeep, Jun Eul Hwang, Hee‐Jin Jang, Hyun‐Sung Lee, Rajesha Rupaimoole, Gabriel Lopez‐Berestein, Woojin Jeong, Inn Sun Park, Young Nyun Park, Anil K. Sood, Gordon B. Mills, Ju‐Seog Lee – 21 September 2015 – Metabolic activation is a common feature of many cancer cells and is frequently associated with the clinical outcomes of various cancers, including hepatocellular carcinoma.

Prevention of hepatitis C virus infection using a broad cross‐neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate

Daire O'Shea, John Law, Adrian Egli, Donna Douglas, Gary Lund, Sarah Forester, Joshua Lambert, Mansun Law, Dennis R. Burton, D. L. J. Tyrrell, Michael Houghton, Atul Humar, Norman Kneteman – 21 September 2015 – The anti–hepatitis C virus (HCV) activity of a novel monoclonal antibody (mAb; AR4A) and epigallocatechin gallate (EGCG) were studied in vitro using a HCV cell culture system and in vivo using a humanized liver mouse model capable of supporting HCV replication.

Outflow reconstruction for right liver allograft with multiple hepatic veins: “V‐plasty” of hepatic veins to form a common outflow channel versus 2 or more hepatic vein–to–inferior vena cava anastomoses in limited retrohepatic space

Ashok Thorat, Long‐Bin Jeng, Horng‐Ren Yang, Ping‐Chun Li, Ming‐Li Li, Chun‐Chieh Yeh, Te‐Hung Chen, Shih‐Chao Hsu, Kin‐Shing Poon – 21 September 2015 – Outflow reconstruction in living donor liver transplantation (LDLT) is certainly difficult in limited retrohepatic space with using right liver grafts with venous anomalies. Venoplasty of the inferior right hepatic veins (IRHVs) and middle hepatic vein (MHV) reconstruction using synthetic grafts to form a common outflow channel or a second venocaval anastomosis are available options.

Subnormothermic ex vivo liver perfusion is a safe alternative to cold static storage for preserving standard criteria grafts

Vinzent N. Spetzler, Nicolas Goldaracena, Juan Echiverri, J. Moritz Kaths, Kristine S. Louis, Oyedele A. Adeyi, Paul M. Yip, David R. Grant, Nazia Selzner, Markus Selzner – 21 September 2015 – We developed a novel technique of subnormothermic ex vivo liver perfusion (SNEVLP) for the storage of liver grafts before transplantation. To test the safety of SNEVLP for the nonextended criteria grafts (standard grafts), we compared it to a control group with minimal cold static storage (CS) time. Heart‐beating pig liver retrieval was performed.

Hepatitis C treatment as prevention of viral transmission and liver‐related morbidity in persons who inject drugs

Anthony Cousien, Viet Chi Tran, Sylvie Deuffic‐Burban, Marie Jauffret‐Roustide, Jean‐Stéphane Dhersin, Yazdan Yazdanpanah – 21 September 2015 – Hepatitis C virus (HCV) seroprevalence remains high in people who inject drug (PWID) populations, often above 60%. Highly effective direct‐acting antiviral (DAA) regimens (90% efficacy) are becoming available for HCV treatment. This therapeutic revolution raises the possibility of eliminating HCV from this population. However, for this, an effective cascade of care is required.

Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining

Keito Yoshimura, Takeshi Okanoue, Hayao Ebise, Tsuyoshi Iwasaki, Masayuki Mizuno, Toshihide Shima, Junji Ichihara, Kazuto Yamazaki – 21 September 2015 – It is important that patients with nonalcoholic steatohepatitis (NASH) are diagnosed and treated early to prevent serious complications, such as liver cirrhosis or hepatocellular carcinoma. However, current methods for NASH diagnosis are invasive given that they rely on liver biopsy, making early diagnosis difficult. In this study, we developed novel noninvasive markers for the diagnosis of NASH and NASH‐related fibrosis.

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