Julieta Marrone, Leandro R. Soria, Mauro Danielli, Guillermo L. Lehmann, Maria Cecilia Larocca, Raúl A. Marinelli – 21 March 2016 – The adenoviral gene transfer of human aquaporin‐1 (hAQP1) water channels to the liver of 17α‐ethinylestradiol‐induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1‐mediated osmotic water secretion. To gain insight into the mechanisms of 17α‐ethinylestradiol cholestasis improvement, we studied the biliary output of bile salts (BS) and the functional expression of the canalicular BS export pump (BSEP; ABCB11).

Xu Yang, Xiao‐peng Tang, Yong‐hong Zhang, Kai‐zhong Luo, Yong‐fang Jiang, Hong‐yu Luo, Jian‐hua Lei, Wen‐long Wang, Ming‐ming Li, Han‐chun Chen, Shi‐lin Deng, Li‐ying Lai, Jun Liang, Min Zhang, Yi Tian, Yun Xu – 21 March 2016

Zongxin Ling, Xia Liu, Yiwen Cheng, Lanjuan Li – 21 March 2016

Julien Bissonnette, Juan Carlos Garcia‐Pagán, Agustín Albillos, Fanny Turon, Carlos Ferreira, Luis Tellez, Jean‐Charles Nault, Nicolas Carbonell, Jean‐Paul Cervoni, Mohamed Abdel Rehim, Annie Sibert, Louis Bouchard, Pierre Perreault, Jonel Trebicka, Félix Trottier‐Tellier, Pierre‐Emmanuel Rautou, Dominique‐Charles Valla, Aurélie Plessier – 17 March 2016 – Idiopathic noncirrhotic portal hypertension is a heterogeneous group of diseases characterized by portal hypertension in the absence of cirrhosis.

Quan Rao, Bingfeng Zuo, Zhen Lu, Xianjun Gao, Abin You, Chenxuan Wu, Zhi Du, HaiFang Yin – 17 March 2016 – Hepatocellular carcinoma (HCC) remains a global challenge due to high morbidity and mortality rates and poor response to treatment. Immunotherapy, based on introduction of dendritic cells (DCs) activated by tumor cell lysates as antigens ex vivo, shows limited response rates in HCC patients. Here, we demonstrate that tumor cell–derived exosomes (TEXs), displaying an array of HCC antigens, can elicit a stronger immune response than cell lysates in vitro and in vivo.

Salvatore Petta, Antonio Craxì – 17 March 2016

Fasiha Kanwal, Steven M. Asch, Jennifer R. Kramer, Yumei Cao, Sumeet Asrani, Hashem B. El‐Serag – 17 March 2016 – Preventing readmission has been the focus of numerous quality improvement efforts across many conditions. Early outpatient follow‐up has been proposed as the best mechanism for reducing readmissions. The extent to which early outpatient follow‐up averts readmission or improves outcomes in cirrhosis is not known. We evaluated the relationship between early outpatient follow‐up and short‐term readmission and mortality in patients with cirrhosis.

Hugo E. Vargas – 17 March 2016

Raluca Wroblewski, Marietta Armaka, Vangelis Kondylis, Manolis Pasparakis, Henning Walczak, Hans‐Willi Mittrücker, Christoph Schramm, Ansgar W. Lohse, George Kollias, Hanno Ehlken – 17 March 2016 – Death receptor (DR) ligands such as tumor necrosis factor (TNF) have been identified as fundamental mediators of liver damage both in mouse models and in humans. While the essential site of function of DR signaling is conceivably the hepatocyte, a systematic analysis is missing.

Andrew B. Adams, Kenneth A. Newell – 17 March 2016