Development of hyperdynamic circulation and response to β‐blockers in compensated cirrhosis with portal hypertension

Càndid Villanueva, Agustín Albillos, Joan Genescà, Juan G. Abraldes, Jose L. Calleja, Carles Aracil, Rafael Bañares, Rosa Morillas, María Poca, Beatriz Peñas, Salvador Augustin, Joan Carles Garcia‐Pagan, Oana Pavel, Jaume Bosch – 30 September 2015 – Nonselective β‐blockers are useful to prevent bleeding in patients with cirrhosis and large varices but not to prevent the development of varices in those with compensated cirrhosis and portal hypertension (PHT). This suggests that the evolutionary stage of PHT may influence the response to β‐blockers.

Dopamine impairs functional integrity of rat hepatocytes through nuclear factor kappa B activity modulation: An in vivo, ex vivo, and in vitro study

Cheuk‐Kwan Sun, Ying‐Hsien Kao, Po‐Huang Lee, Ming‐Chang Wu, Kun‐Cho Chen, Yu‐Chun Lin, Ming‐Shian Tsai, Po‐Han Chen – 30 September 2015 – Dopamine (DA) is commonly used to maintain the hemodynamic stability of brain‐dead donors despite its controversial effects on organ functions.

Determinants of outcome among patients with acute liver failure listed for liver transplantation in the United States

K. Rajender Reddy, Caitlyn Ellerbe, Michael Schilsky, R. Todd Stravitz, Robert J. Fontana, Valerie Durkalski, William M. Lee, and the Acute Liver Failure Study Group – 30 September 2015 – Analyses of outcomes after acute liver failure (ALF) have typically included all ALF patients regardless of whether they were listed for liver transplantation (LT). We hypothesized that limiting analysis to listed patients might provide novel insights into factors associated with outcome, focusing attention on disease evolution after listing.

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Christine E. McLaren, James C. Barton, Pradyumna D. Phatak, Mary J. Emond, V. Nathan Subramaniam, Lyle C. Gurrin, Paul C. Adams, Lawrie W. Powell, Grant A. Ramm, Gregory J. Anderson, Gordon D. McLaren – 29 September 2015

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