Further evidence on the janus‐faced nature of the epidermal growth factor receptor: From liver regeneration to hepatocarcinogenesis
Carmen Berasain, Matias A. Avila – 24 September 2015
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Satoru Hagiwara, Naoshi Nishida, Masatoshi Kudo – 24 September 2015
A novel role for hepatic stellate cells in pathogenesis of visceral leishmaniasis
Naglaa H. Shoukry, Thomas Fabre, Chandrashekhar R. Gandhi – 24 September 2015
Role of ABCG2 in liver injury associated with erythropoietic protoporphyria
Madhav Sachar, Xiaochao Ma – 24 September 2015
Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
Xiaofang Sun, Zhanhui Ou, Ruochan Chen, Xiaohua Niu, De Chen, Rui Kang, Daolin Tang – 24 September 2015 – Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐dependent accumulation of lipid reactive oxygen species. However, the molecular mechanisms regulating ferroptosis remain obscure. Here, we report that nuclear factor erythroid 2‐related factor 2 (NRF2) plays a central role in protecting hepatocellular carcinoma (HCC) cells against ferroptosis.
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice
Karim Gariani, Keir J. Menzies, Dongryeol Ryu, Casey J. Wegner, Xu Wang, Eduardo R. Ropelle, Norman Moullan, Hongbo Zhang, Alessia Perino, Vera Lemos, Bohkyung Kim, Young‐Ki Park, Alessandra Piersigilli, Tho X. Pham, Yue Yang, Chai Siah Ku, Sung I. Koo, Anna Fomitchova, Carlos Cantó, Kristina Schoonjans, Anthony A.
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice
Karim Gariani, Keir J. Menzies, Dongryeol Ryu, Casey J. Wegner, Xu Wang, Eduardo R. Ropelle, Norman Moullan, Hongbo Zhang, Alessia Perino, Vera Lemos, Bohkyung Kim, Young‐Ki Park, Alessandra Piersigilli, Tho X. Pham, Yue Yang, Chai Siah Ku, Sung I. Koo, Anna Fomitchova, Carlos Cantó, Kristina Schoonjans, Anthony A.
Vasopressin 1a receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats
Guillermo Fernández‐Varo, Denise Oró, Edward Earl Cable, Vedrana Reichenbach, Silvia Carvajal, Bernardino González de la Presa, Kazimierz Wiśniewski, Pere Ginés, Geoffrey Harris, Wladimiro Jiménez – 24 September 2015 – Patients and rats with cirrhosis and ascites have portal hypertension and circulatory dysfunction. Synthetic arginine vasopressin (AVP) receptor agonists able to induce systemic and mesenteric vasoconstriction have shown their usefulness in reducing portal pressure (PP) in this condition.
Let the bile flow!
Rohit Kohli, Kenneth D.R. Setchell – 22 September 2015
Let the bile flow!
Rohit Kohli, Kenneth D.R. Setchell – 22 September 2015