Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta‐omics‐based approach

Federica Del Chierico, Valerio Nobili, Pamela Vernocchi, Alessandra Russo, Cristiano De Stefanis, Daniela Gnani, Cesare Furlanello, Alessandro Zandonà, Paola Paci, Giorgio Capuani, Bruno Dallapiccola, Alfredo Miccheli, Anna Alisi, Lorenza Putignani – 29 March 2016 – There is evidence that nonalcoholic fatty liver disease (NAFLD) is affected by gut microbiota. Therefore, we investigated its modifications in pediatric NAFLD patients using targeted metagenomics and metabolomics.

Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Alan Ka‐Lun Kai, Lo Kong Chan, Regina Cheuk‐Lam Lo, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Jack Chun‐Ming Wong, Irene Oi‐Lin Ng – 28 March 2016 – Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of hepatocellular carcinoma (HCC) metastasis.

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