The dual and opposite role of the TM6SF2‐rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta‐analysis

Carlos J. Pirola, Silvia Sookoian – 1 September 2015 – The aim of this work was to estimate the strength of the effect of the TM6SF2 E167K (rs58542926 C/T) variant on blood lipid traits and nonalcoholic fatty liver disease (NAFLD) across different populations. We performed a systematic review by a meta‐analysis; literature searches identified 10 studies. The rs58542926 exerts a significant role in modulating lipid traits, including total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), triglycerides (TG), and NAFLD.

Impaired monocyte‐macrophage functions and defective toll‐like receptor signaling in hepatitis E virus‐infected pregnant women with acute liver failure

Rashi Sehgal, Sharda Patra, Paul David, Ashish Vyas, Arshi Khanam, Syed Hissar, Ekta Gupta, Guresh Kumar, Shyam Kottilil, Rakhi Maiwall, Shiv Kumar Sarin, Nirupama Trehanpati – 31 August 2015 – Acute viral hepatitis resulting due to hepatitis E viral infection (AVH‐E) is often serious in pregnancy and could result in acute liver failure (ALF). The role of monocytes and macrophages (mono‐macs) in the pathogenesis of AVH‐E and development of ALF‐E in pregnancy is unclear.

Impaired monocyte‐macrophage functions and defective toll‐like receptor signaling in hepatitis E virus‐infected pregnant women with acute liver failure

Rashi Sehgal, Sharda Patra, Paul David, Ashish Vyas, Arshi Khanam, Syed Hissar, Ekta Gupta, Guresh Kumar, Shyam Kottilil, Rakhi Maiwall, Shiv Kumar Sarin, Nirupama Trehanpati – 31 August 2015 – Acute viral hepatitis resulting due to hepatitis E viral infection (AVH‐E) is often serious in pregnancy and could result in acute liver failure (ALF). The role of monocytes and macrophages (mono‐macs) in the pathogenesis of AVH‐E and development of ALF‐E in pregnancy is unclear.

Longterm health‐related quality of life after living liver donation

Vanessa R. Humphreville, David M. Radosevich, Abhinav Humar, William D. Payne, Raja Kandaswamy, John R. Lake, Arthur J. Matas, Timothy L. Pruett, Srinath Chinnakotla – 31 August 2015 – There are little data on longterm outcomes, health‐related quality of life (HRQoL), and issues related to living donor right hepatectomy specifically. We studied longterm HRQoL in 127 living liver donors.

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