Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

Zobair M. Younossi, Munkhzul Otgonsuren, Linda Henry, Chapy Venkatesan, Alita Mishra, Madeline Erario, Sharon Hunt – 14 August 2015 – Hepatocellular carcinoma (HCC) is increasingly reported in patients with nonalcoholic fatty liver disease (NAFLD). Our aim was to assess the prevalence and mortality of patients with NAFLD‐HCC.

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

Zobair M. Younossi, Munkhzul Otgonsuren, Linda Henry, Chapy Venkatesan, Alita Mishra, Madeline Erario, Sharon Hunt – 14 August 2015 – Hepatocellular carcinoma (HCC) is increasingly reported in patients with nonalcoholic fatty liver disease (NAFLD). Our aim was to assess the prevalence and mortality of patients with NAFLD‐HCC.

Liver receptor homolog‐1 is a critical determinant of methyl‐pool metabolism

Martin Wagner, Sungwoo Choi, Katrin Panzitt, Jennifer L. Mamrosh, Jae Man Lee, Alex Zaufel, Rui Xiao, Ruth Wooton‐Kee, Marcus Ståhlman, Christopher B. Newgard, Jan Borén, David D. Moore – 12 August 2015 – Balance of labile methyl groups (choline, methionine, betaine, and folate) is important for normal liver function. Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog‐1 (LRH‐1).

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis

Shinji Shimoda, Satomi Hisamoto, Kenichi Harada, Sho Iwasaka, Yong Chong, Minoru Nakamura, Yuki Bekki, Tomoharu Yoshizumi, Ken Shirabe, Toru Ikegami, Yoshihiko Maehara, Xiao‐Song He, M. Eric Gershwin, Koichi Akashi – 11 August 2015 – The hallmark of primary biliary cirrhosis (PBC) is the presence of autoreactive T‐ and B‐cell responses that target biliary epithelial cells (BECs). Biliary cell cytotoxicity is dependent upon initiation of innate immune responses followed by chronic adaptive, as well as bystander, mechanisms.

Once‐daily prolonged release tacrolimus in liver transplantation: Experts' literature review and recommendations

Audrey Coilly, Yvon Calmus, Faiza Chermak, Jerome Dumortier, Christophe Duvoux, Olivier Guillaud, Pauline Houssel‐Debry, Martine Neau‐Cransac, Jeanick Stocco – 11 August 2015 – The efficacy and safety of tacrolimus (Tac) twice daily (bid) and once a day (qd) formulations are considered to be similar. However, the available information regarding initiation of Tac qd is sparse, and practical information is lacking.

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