Amanda J. Craig, Augusto Villanueva – 9 February 2016

Amanda J. Craig, Augusto Villanueva – 9 February 2016

Wei Wu, Ami Patel, Kaisa Kyöstilä, Hannes Lohi, Nikol Mladkova, Krzysztof Kiryluk, Xiaoyun Sun, Jay H. Lefkowitch, Howard J. Worman, Ali G. Gharavi – 9 February 2016 – Using publicly available data from inbred mouse strains, we conducted a genome‐wide association study to identify loci that accounted for liver‐related phenotypes between C57BL/6J and A/J mice fed a Paigen diet. We confirmed genome‐wide significant associations for hepatic cholesterol (chromosome 10A2) and serum total bile acid concentration (chromosome 12E) and identified a new locus for liver inflammation (chromosome 7C).

Li Guan, Lei Zhang, Zhicheng Gong, Xiaonan Hou, Yuxiu Xu, Xinhua Feng, Hongyang Wang, Han You – 9 February 2016 – FoxO transcription factors have been reported to play pivotal roles in tumorigenesis and drug resistance. The mechanisms underlying the tumor suppression function of FoxOs in human cancers remain largely unknown. Aberrant expression and activation of Nrf2 often correlate with chemoresistance and poor prognosis. Here, we report that FoxO3 directs the basal transcription of Kelch‐like ECH‐associated protein 1 (Keap1), an adaptor protein that bridges Nrf2 to Cul3 for degradation.

Christophe Hézode, Stéphane Chevaliez, Giovanna Scoazec, Alexandre Soulier, Anne Varaut, Magali Bouvier‐Alias, Isaac Ruiz, Françoise Roudot‐Thoraval, Ariane Mallat, Cyrille Féray, Jean‐Michel Pawlotsky – 8 February 2016 – Failure to achieve sustained virological response (SVR) with hepatitis C virus (HCV) direct‐acting antiviral‐based regimens is commonly associated with emergence of resistance‐associated variants (RAVs).

Nam‐On Ku, Pavel Strnad, Heike Bantel, M. Bishr Omary – 8 February 2016 – Keratins, formerly known as cytokeratins, are the major epithelial‐specific subgroup of intermediate filament proteins. Adult hepatocytes express keratin polypeptides 8 and 18 (K8/K18), whereas cholangiocytes express K8/K18 and keratins 7 and 19 (K7/K19). Keratins function primarily to protect hepatocytes from apoptosis and necrosis, which was revealed using several genetic mouse models.

Benjamin L. Woolbright, Hartmut Jaeschke – 8 February 2016

Ramesh Kudira, Thomas Malinka, Andreas Kohler, Michel Dosch, Mercedes Gomez de Agüero, Nicolas Melin, Stefanie Haegele, Patrick Starlinger, Niran Maharjan, Smita Saxena, Adrian Keogh, Deborah Stroka, Daniel Candinas, Guido Beldi – 8 February 2016 – Paracrine signalling mediated by cytokine secretion is essential for liver regeneration after hepatic resection, yet the mechanisms of cellular crosstalk between immune and parenchymal cells are still elusive. Interleukin‐22 (IL‐22) is released by immune cells and mediates strong hepatoprotective functions.

Nam‐On Ku, Pavel Strnad, Heike Bantel, M. Bishr Omary – 8 February 2016 – Keratins, formerly known as cytokeratins, are the major epithelial‐specific subgroup of intermediate filament proteins. Adult hepatocytes express keratin polypeptides 8 and 18 (K8/K18), whereas cholangiocytes express K8/K18 and keratins 7 and 19 (K7/K19). Keratins function primarily to protect hepatocytes from apoptosis and necrosis, which was revealed using several genetic mouse models.

Christophe Hézode, Stéphane Chevaliez, Giovanna Scoazec, Alexandre Soulier, Anne Varaut, Magali Bouvier‐Alias, Isaac Ruiz, Françoise Roudot‐Thoraval, Ariane Mallat, Cyrille Féray, Jean‐Michel Pawlotsky – 8 February 2016 – Failure to achieve sustained virological response (SVR) with hepatitis C virus (HCV) direct‐acting antiviral‐based regimens is commonly associated with emergence of resistance‐associated variants (RAVs).