Liver receptor homolog‐1 is a critical determinant of methyl‐pool metabolism
Martin Wagner, Sungwoo Choi, Katrin Panzitt, Jennifer L. Mamrosh, Jae Man Lee, Alex Zaufel, Rui Xiao, Ruth Wooton‐Kee, Marcus Ståhlman, Christopher B. Newgard, Jan Borén, David D. Moore – 12 August 2015 – Balance of labile methyl groups (choline, methionine, betaine, and folate) is important for normal liver function. Quantitatively, a significant use of labile methyl groups is in the production of phosphatidylcholines (PCs), which are ligands for the nuclear liver receptor homolog‐1 (LRH‐1).