Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi)

Shakeel M. Thakurdas, Mario F. Lopez, Shinako Kakuda, Rodrigo Fernandez‐Valdivia, Neda Zarrin‐Khameh, Robert S. Haltiwanger, Hamed Jafar‐Nejad – 1 August 2015 – Haploinsufficiency for the Notch ligand JAG1 in humans results in an autosomal‐dominant, multisystem disorder known as Alagille syndrome, which is characterized by a congenital cholangiopathy of variable severity.

De novo hepatic steatosis drives atherogenic risk in liver transplantation recipients

Michael O. Idowu, Ravi Chhatrala, M. Bilal Siddiqui, Carolyn Driscoll, R. Todd Stravitz, Arun J. Sanyal, Chandra Bhati, Carol Sargeant, Velimir A. Luketic, Richard K. Sterling, Melissa Contos, Scott Matherly, Puneet Puri, M. Shadab Siddiqui – 30 July 2015 – Nonalcoholic fatty liver disease is associated with cardiovascular disease (CVD) in the general population. Despite a high prevalence of de novo hepatic steatosis after liver transplantation (LT), there are no data exploring the association between hepatic steatosis after LT and atherogenic risk.

Impact of the serum ferritin concentration in liver transplantation

Taiichi Wakiya, Yukihiro Sanada, Taizen Urahashi, Yoshiyuki Ihara, Naoya Yamada, Noriki Okada, Yuta Hirata, Kenichi Hakamada, Yoshikazu Yasuda, Koichi Mizuta – 29 July 2015 – The serum ferritin (SF) concentration is a widely available and objective laboratory parameter. SF is also widely recognized as an acute‐phase reactant. The purpose of the present study was to identify the chronological changes in the recipient's SF concentration during liver transplantation (LT) and to clarify factors having an effect on the recipient's intraoperative SF level.

Quantitative magnetic resonance imaging of hepatic steatosis: Validation in ex vivo human livers

Peter Bannas, Harald Kramer, Diego Hernando, Rashmi Agni, Ashley M. Cunningham, Rakesh Mandal, Utaroh Motosugi, Samir D. Sharma, Alejandro Munoz del Rio, Luis Fernandez, Scott B. Reeder – 29 July 2015 – Emerging magnetic resonance imaging (MRI) biomarkers of hepatic steatosis have demonstrated tremendous promise for accurate quantification of hepatic triglyceride concentration. These methods quantify the proton density fat‐fraction (PDFF), which reflects the concentration of triglycerides in tissue.

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Amélie Weiss, Mickaël Renaud, Sarah C. Durand, François Habersetzer, David Durantel, Georges Abou‐Jaoudé, Maria M. López Ledesma, Daniel J. Felmlee, Magali Soumillon, Tom Croonenborghs, Nathalie Pochet, Michael Nassal, Catherine Schuster, Laurent Brino, Camille Sureau, Mirjam B. Zeisel, Thomas F. Baumert – 29 July 2015 – Chronic hepatitis B and D infections are major causes of liver disease and hepatocellular carcinoma worldwide. Efficient therapeutic approaches for cure are absent.

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