Prevalence of chronic hepatitis B virus (HBV) infection in U.S. households: National Health and Nutrition Examination Survey (NHANES), 1988‐2012

Henry Roberts, Deanna Kruszon‐Moran, Kathleen N. Ly, Elizabeth Hughes, Kashif Iqbal, Ruth B. Jiles, Scott D. Holmberg – 6 August 2015 – The number of persons with chronic hepatitis B virus (HBV) infection in the United States is affected by diminishing numbers of young persons who are susceptible because of universal infant vaccination since 1991, offset by numbers of HBV‐infected persons migrating to the United States from endemic countries.

High priority for hepatitis C screening in safety net hospitals: Results from a prospective cohort of 4582 hospitalized baby boomers

Barbara J. Turner, Barbara S. Taylor, Joshua Hanson, Yuanyuan Liang, Poornachand Veerapaneni, Roberto Villarreal, Mary Perez, Ludivina Hernandez, Jasdeep Sandhu, Kristin Fiebelkorn – 6 August 2015 – Low‐income populations are disproportionately affected by hepatitis C virus (HCV) infection. Thus, implementing baby boomer screening (born 1945‐1965) for HCV may be a high priority for safety net hospitals.

Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune‐mediated hepatitis

Tomoko Fujita, Kitipong Soontrapa, Yoshiya Ito, Keiko Iwaisako, Catharina Sagita Moniaga, Masataka Asagiri, Masataka Majima, Shuh Narumiya – 6 August 2015 – Hepatic stellate cells (HSCs) constitute the liver sinusoid with Kupffer cells and liver sinusoidal endothelial cells. While the sinusoid functions as the gateway to liver inflammation, whether HSCs contribute to liver inflammation and, if so, how they exert such functions remain elusive. Here, we found that mouse as well as human HSCs expressed DP1 receptor for prostaglandin D2 selectively in the liver.

The prognostic value of hepatic venous pressure gradient in patients with cirrhosis is highly dependent on the accuracy of the technique

Gilberto Silva‐Junior, Anna Baiges, Fanny Turon, Ferran Torres, Virginia Hernández‐Gea, Jaime Bosch, Juan Carlos García‐Pagán – 3 August 2015 – Hepatic venous pressure gradient (HVPG), the difference between wedged (WHVP) and free hepatic vein pressure (FHVP), predicts survival in patients with cirrhosis. It has been suggested for the use of inferior vena cava (IVC) value instead of FHVP to calculate HVPG when the difference between proximal FHVP (obtained at 2 cm from the hepatic vein outlet) and IVC (measured at the level of the hepatic ostium) is >2 mm Hg.

Present and future therapies of hepatitis B: From discovery to cure

T. Jake Liang, Timothy M. Block, Brian J. McMahon, Marc G. Ghany, Stephan Urban, Ju‐Tao Guo, Stephen Locarnini, Fabien Zoulim, Kyong‐Mi Chang, Anna S. Lok – 3 August 2015 – Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require lifelong therapies and cure is still a challenging goal.

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