Baclofen for the treatment of muscle cramps in patients with cirrhosis: A new alternative
Zachary H. Henry, Patrick G. Northup – 14 July 2015
CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis
Kai Markus Schneider, Veerle Bieghs, Felix Heymann, Wei Hu, Daniela Dreymueller, Lijun Liao, Mick Frissen, Andreas Ludwig, Nikolaus Gassler, Oliver Pabst, Eicke Latz, Gernot Sellge, John Penders, Frank Tacke, Christian Trautwein – 14 July 2015 – Nonalcoholic fatty liver disease is seen as the hepatic manifestation of the metabolic syndrome and represents the most common liver disease in Western societies. The G protein–coupled chemokine receptor CX3CR1 plays a central role in several metabolic syndrome–related disease manifestations and is involved in maintaining intestinal homeostasis.
Depletion of B cells induces remission of autoimmune hepatitis in mice through reduced antigen presentation and help to T cells
Kathie Béland, Gabriel Marceau, Agathe Labardy, Sara Bourbonnais, Fernando Alvarez – 14 July 2015 – Autoimmune hepatitis (AIH) is known as a T cell–mediated disease. However, AIH patients refractory to conventional treatment have been successfully treated with anti‐CD20‐mediated B‐cell depletion. The aim of this project was to understand the immunological changes underlying the AIH remission caused by B‐cell depletion in an experimental model of AIH.
Is hepatitis E virus an emerging problem in industrialized countries?
Ibrahim M. Sayed, Ann‐Sofie Vercouter, Sayed F. Abdelwahab, Koen Vercauteren, Philip Meuleman – 14 July 2015 – Hepatitis E virus (HEV) is yearly responsible for approximately 20 million infections worldwide. Although most infections occur in developing countries, HEV appears to be an emerging problem in several industrialized countries, where it is mostly associated with either traveling to an HEV endemic area or contact with pigs, which represent a major reservoir of HEV.
NUMB phosphorylation destabilizes p53 and promotes self‐renewal of tumor‐initiating cells by a NANOG‐dependent mechanism in liver cancer
Hifzur R. Siddique, Douglas E. Feldman, Chia‐Lin Chen, Vasu Punj, Hiroshi Tokumitsu, Keigo Machida – 14 July 2015 – Stem cell populations are maintained through self‐renewing divisions in which one daughter cell commits to a particular fate whereas the other retains the multipotent characteristics of its parent. The NUMB, a tumor suppressor, in conjunction with another tumor‐suppressor protein, p53, preserves this property and acts as a barrier against deregulated expansion of tumor‐associated stem cells.
Correction
14 July 2015
Hepatic surgeons are like the child who rescued dying fishes
Tian Yang, Wan Yee Lau, Han Zhang, Meng‐Chao Wu, Feng Shen – 14 July 2015
Reply to: “Impaired expression of multidrug resistance–associated protein 2 and liver damage in erythropoietic protoporphyria”
Vincent W. Bloks, Torsten Plösch, Johan W. Jonker, Folkert Kuipers – 14 July 2015
Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells
Yanan Wang, Sam van der Tuin, Nathanja Tjeerdema, Andrea D. van Dam, Sander S. Rensen, Tim Hendrikx, Jimmy F.P. Berbée, Biljana Atanasovska, Jingyuan Fu, Menno Hoekstra, Siroon Bekkering, Niels P. Riksen, Wim A. Buurman, Jan Willem Greve, Marten H. Hofker, Ronit Shiri‐Sverdlov, Onno C. Meijer, Johannes W.A. Smit, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen – 14 July 2015 – The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established.