YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Patricia Marti, Claudia Stein, Tanja Blumer, Yann Abraham, Michael T. Dill, Monika Pikiolek, Vanessa Orsini, Giorgia Jurisic, Philippe Megel, Zuzanna Makowska, Claudia Agarinis, Luigi Tornillo, Tewis Bouwmeester, Heinz Ruffner, Andreas Bauer, Christian N. Parker, Tobias Schmelzle, Luigi M. Terracciano, Markus H. Heim, Jan S. Tchorz – 14 July 2015 – The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not established.

Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study

Edith M. Koehler, Elisabeth P.C. Plompen, Jeoffrey N.L. Schouten, Bettina E. Hansen, Sarwa Darwish Murad, Pavel Taimr, Frank W.G. Leebeek, Albert Hofman, Bruno H. Stricker, Laurent Castera, Harry L.A. Janssen – 14 July 2015 – Given that little is known about the prevalence of, and factors associated with, liver fibrosis in the general population, we aimed to investigate this in a large, well‐characterized cohort by means of transient elastography (TE). This study was part of the Rotterdam Study, a population‐based study among individuals ≥45 years.

Age and equity in liver transplantation: An organ allocation model

Alessandro Cucchetti, Lainie Friedman Ross, J. Richard Thistlethwaite, Alessandro Vitale, Matteo Ravaioli, Matteo Cescon, Giorgio Ercolani, Patrizia Burra, Umberto Cillo, Antonio Daniele Pinna – 14 July 2015 – A moral liver allocation policy must be fair. We considered a 2‐step, 2‐principle allocation system called “age mapping.” Its first principle, equal opportunity, ensures that candidates of all ages have an equal chance of getting an organ.

Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice

Alexander G. Miethke, Wujuan Zhang, Julia Simmons, Amy E. Taylor, Tiffany Shi, Shiva Kumar Shanmukhappa, Rebekah Karns, Shana White, Anil G. Jegga, Celine S. Lages, Stephenson Nkinin, Bradley T. Keller, Kenneth D.R. Setchell – 14 July 2015 – Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal, apical sodium‐dependent bile acid transporter (ASBT), blocks progression of sclerosing cholangitis in mdr2–/– mice.

Kupffer cell–monocyte communication is essential for initiating murine liver progenitor cell–mediated liver regeneration

Caryn L. Elsegood, Chun Wei Chan, Mariapia A. Degli‐Esposti, Matthew E. Wikstrom, Alice Domenichini, Kyren Lazarus, Nico van Rooijen, Ruth Ganss, John K. Olynyk, George C.T. Yeoh – 14 July 2015 – Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease because the remaining hepatocytes cannot replicate. However, LPC numbers also correlate with disease severity and hepatocellular carcinoma risk. Thus, the progenitor cell response in diseased liver may be regulated to optimize liver regeneration and minimize the likelihood of tumorigenesis.

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