B cells expressing CD11b effectively inhibit CD4+ T‐cell responses and ameliorate experimental autoimmune hepatitis in mice

Xiaoming Liu, Xuechao Jiang, Ronghua Liu, Luman Wang, Tingting Qian, Yijie Zheng, Yuting Deng, Enyu Huang, Fengkai Xu, Ji‐Yang Wang, Yiwei Chu – 24 July 2015 – Increasing evidence in recent years has suggested that B cells act as a crucial regulator in autoimmune diseases. However, little is known about their role in autoimmune hepatitis (AIH) and the underlying regulatory mechanisms. In this study, we show that B cells ameliorated experimental AIH (EAH) by suppressing CD4+ T‐cell responses and that CD11b expression on B cells was required for the regulatory function of B cells.

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