Kai Markus Schneider, Veerle Bieghs, Felix Heymann, Wei Hu, Daniela Dreymueller, Lijun Liao, Mick Frissen, Andreas Ludwig, Nikolaus Gassler, Oliver Pabst, Eicke Latz, Gernot Sellge, John Penders, Frank Tacke, Christian Trautwein – 14 July 2015 – Nonalcoholic fatty liver disease is seen as the hepatic manifestation of the metabolic syndrome and represents the most common liver disease in Western societies. The G protein–coupled chemokine receptor CX3CR1 plays a central role in several metabolic syndrome–related disease manifestations and is involved in maintaining intestinal homeostasis.

Kathie Béland, Gabriel Marceau, Agathe Labardy, Sara Bourbonnais, Fernando Alvarez – 14 July 2015 – Autoimmune hepatitis (AIH) is known as a T cell–mediated disease. However, AIH patients refractory to conventional treatment have been successfully treated with anti‐CD20‐mediated B‐cell depletion. The aim of this project was to understand the immunological changes underlying the AIH remission caused by B‐cell depletion in an experimental model of AIH.

Ibrahim M. Sayed, Ann‐Sofie Vercouter, Sayed F. Abdelwahab, Koen Vercauteren, Philip Meuleman – 14 July 2015 – Hepatitis E virus (HEV) is yearly responsible for approximately 20 million infections worldwide. Although most infections occur in developing countries, HEV appears to be an emerging problem in several industrialized countries, where it is mostly associated with either traveling to an HEV endemic area or contact with pigs, which represent a major reservoir of HEV.

Hifzur R. Siddique, Douglas E. Feldman, Chia‐Lin Chen, Vasu Punj, Hiroshi Tokumitsu, Keigo Machida – 14 July 2015 – Stem cell populations are maintained through self‐renewing divisions in which one daughter cell commits to a particular fate whereas the other retains the multipotent characteristics of its parent. The NUMB, a tumor suppressor, in conjunction with another tumor‐suppressor protein, p53, preserves this property and acts as a barrier against deregulated expansion of tumor‐associated stem cells.

14 July 2015

Tian Yang, Wan Yee Lau, Han Zhang, Meng‐Chao Wu, Feng Shen – 14 July 2015

Vincent W. Bloks, Torsten Plösch, Johan W. Jonker, Folkert Kuipers – 14 July 2015

14 July 2015

Yanan Wang, Sam van der Tuin, Nathanja Tjeerdema, Andrea D. van Dam, Sander S. Rensen, Tim Hendrikx, Jimmy F.P. Berbée, Biljana Atanasovska, Jingyuan Fu, Menno Hoekstra, Siroon Bekkering, Niels P. Riksen, Wim A. Buurman, Jan Willem Greve, Marten H. Hofker, Ronit Shiri‐Sverdlov, Onno C. Meijer, Johannes W.A. Smit, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen – 14 July 2015 – The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established.

Brian R. Edlin, Benjamin J. Eckhardt, Marla A. Shu, Scott D. Holmberg, Tracy Swan – 14 July 2015 – Data from the 2003‐2010 National Health and Nutrition Examination Survey (NHANES) indicate that about 3.6 million people in the United States have antibodies to the hepatitis C virus, of whom 2.7 million are currently infected. NHANES, however, excludes several high‐risk populations from its sampling frame, including people who are incarcerated, homeless, or hospitalized; nursing home residents; active‐duty military personnel; and people living on Indian reservations.