Age and equity in liver transplantation: An organ allocation model

Alessandro Cucchetti, Lainie Friedman Ross, J. Richard Thistlethwaite, Alessandro Vitale, Matteo Ravaioli, Matteo Cescon, Giorgio Ercolani, Patrizia Burra, Umberto Cillo, Antonio Daniele Pinna – 14 July 2015 – A moral liver allocation policy must be fair. We considered a 2‐step, 2‐principle allocation system called “age mapping.” Its first principle, equal opportunity, ensures that candidates of all ages have an equal chance of getting an organ.

Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study

Edith M. Koehler, Elisabeth P.C. Plompen, Jeoffrey N.L. Schouten, Bettina E. Hansen, Sarwa Darwish Murad, Pavel Taimr, Frank W.G. Leebeek, Albert Hofman, Bruno H. Stricker, Laurent Castera, Harry L.A. Janssen – 14 July 2015 – Given that little is known about the prevalence of, and factors associated with, liver fibrosis in the general population, we aimed to investigate this in a large, well‐characterized cohort by means of transient elastography (TE). This study was part of the Rotterdam Study, a population‐based study among individuals ≥45 years.

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Patricia Marti, Claudia Stein, Tanja Blumer, Yann Abraham, Michael T. Dill, Monika Pikiolek, Vanessa Orsini, Giorgia Jurisic, Philippe Megel, Zuzanna Makowska, Claudia Agarinis, Luigi Tornillo, Tewis Bouwmeester, Heinz Ruffner, Andreas Bauer, Christian N. Parker, Tobias Schmelzle, Luigi M. Terracciano, Markus H. Heim, Jan S. Tchorz – 14 July 2015 – The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not established.

Toward a more accurate estimate of the prevalence of hepatitis C in the United States

Brian R. Edlin, Benjamin J. Eckhardt, Marla A. Shu, Scott D. Holmberg, Tracy Swan – 14 July 2015 – Data from the 2003‐2010 National Health and Nutrition Examination Survey (NHANES) indicate that about 3.6 million people in the United States have antibodies to the hepatitis C virus, of whom 2.7 million are currently infected. NHANES, however, excludes several high‐risk populations from its sampling frame, including people who are incarcerated, homeless, or hospitalized; nursing home residents; active‐duty military personnel; and people living on Indian reservations.

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

Yanan Wang, Sam van der Tuin, Nathanja Tjeerdema, Andrea D. van Dam, Sander S. Rensen, Tim Hendrikx, Jimmy F.P. Berbée, Biljana Atanasovska, Jingyuan Fu, Menno Hoekstra, Siroon Bekkering, Niels P. Riksen, Wim A. Buurman, Jan Willem Greve, Marten H. Hofker, Ronit Shiri‐Sverdlov, Onno C. Meijer, Johannes W.A. Smit, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen – 14 July 2015 – The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established.

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