Ming Liu, Leilei Chen, Ning‐Fang Ma, Raymond Kwok Kei Chow, Yan Li, Yangyang Song, Tim Hon Man Chan, Shuo Fang, Xiaodong Yang, Shaoyan Xi, Lingxi Jiang, Yun Li, Ting‐Ting Zeng, Yan Li, Yun‐Fei Yuan, Xin‐Yuan Guan – 11 January 2016 – High‐grade tumors with poor differentiation usually show phenotypic resemblance to their developmental ancestral cells. Cancer cells that gain lineage precursor cell properties usually hijack developmental signaling pathways to promote tumor malignant progression. However, the molecular mechanisms underlying this process remain unclear.

Loren Laine – 11 January 2016

Fred Poordad, Eugene R. Schiff, John M. Vierling, Charles Landis, Robert J. Fontana, Rong Yang, Fiona McPhee, Eric A. Hughes, Stephanie Noviello, Eugene S. Swenson – 11 January 2016 – Chronic hepatitis C virus (HCV) infection with advanced cirrhosis or post‐liver transplantation recurrence represents a high unmet medical need with no approved therapies effective across all HCV genotypes.

Angelo X. C. Fonseca, Fabricio M. Valois, Eloara V. M. Ferreira, Rudolf K. F. Oliveira, Roberta P. Ramos, Carolina M. S. Messina, Camila M. O. Costa, Luiz E. Nery, Jaquelina Ota‐Arakaki – 11 January 2016

Yoshiaki Sunami, Marc Ringelhan, Enikö Kokai, Miao Lu, Tracy O'Connor, Anna Lorentzen, Achim Weber, Ann‐Katrin Rodewald, Beat Müllhaupt, Luigi Terracciano, Sarah Gul, Sebastian Wissel, Frank Leithäuser, Daniel Krappmann, Petra Riedl, Daniel Hartmann, Reinhold Schirmbeck, Pavel Strnad, Norbert Hüser, Jörg Kleeff, Helmut Friess, Roland M Schmid, Fabian Geisler, Thomas Wirth, Mathias Heikenwalder – 11 January 2016 – Chronic hepatitis B virus (HBV) infection remains the most common risk factor for hepatocellular carcinoma (HCC).

Leila Valanejad, Nikolai Timchenko – 11 January 2016

Francisco Javier Cubero – 11 January 2016

Salvatore Piano, Paolo Angeli – 11 January 2016

Shao‐Lai Zhou, Zhi‐Qiang Hu, Zheng‐Jun Zhou, Zhi Dai, Zheng Wang, Ya Cao, Jia Fan, Xiao‐Wu Huang, Jian Zhou – 11 January 2016 – MicroRNAs (miRNAs) play a critical role in regulation of tumor metastasis. However, the role of these molecules in hepatocellular carcinoma (HCC) has not been fully elucidated. In this study, we employed miRNA‐sequencing and identified 22 miRNAs involved in HCC metastasis. One of these, miR‐28‐5p, was down‐regulated in HCCs. This down‐regulation correlated with tumor metastasis, recurrence, and poor survival.

Jean Michel Mansuy, Pierre Gallian, Chloé Dimeglio, Karine Saune, Catherine Arnaud, Bertrand Pelletier, Pascal Morel, Dominique Legrand, Pierre Tiberghien, Jacques Izopet – 11 January 2016 – Most cases of hepatitis E viral (HEV) infection in developed countries are autochthonous. Nevertheless, the reported seroprevalence of HEV varies greatly depending on the geographical area and the performance of the immunoassay used.