Muhammed Yuksel, Yipeng Wang, Ningwen Tai, Jian Peng, Junhua Guo, Kathie Beland, Pascal Lapierre, Chella David, Fernando Alvarez, Isabelle Colle, Huiping Yan, Giorgina Mieli‐Vergani, Diego Vergani, Yun Ma, Li Wen – 16 July 2015 – Autoimmune hepatitis (AIH) in humans is a severe inflammatory liver disease characterized by interface hepatitis, the presence of circulating autoantibodies, and hyper‐gammaglobulinemia. There are two types of AIH, type 1 (AIH‐1) and type 2 (AIH‐2), characterized by distinct autoimmune serology.

Alessandro Vitale, Fabio Farinati, Patrizia Burra, Franco Trevisani, Edoardo G.

16 July 2015

Ezequiel Rodriguez, Gustavo Henrique Pereira, Elsa Solà, Chiara Elia, Rogelio Barreto, Elisa Pose, Jordi Colmenero, Javier Fernandez, Miquel Navasa, Vicente Arroyo, Pere Ginès – 15 July 2015 – There is little information on the effects of treatment with vasoconstrictors plus albumin in patients with type 2 hepatorenal syndrome (HRS), particularly those awaiting liver transplantation (LT). This study reports the effects of treatment of type 2 HRS in patients on the waiting list for LT. We included 56 patients with type 2 HRS who were awaiting LT.

Isobel Ramsay, Luke Snell, Vikram Sharma, James O'Beirne, David Patch, Aileen Marshall, Charles Imber, Samreen Ijaz, Dianne Irish, Rachel H. Westbrook – 15 July 2015

Zachary H. Henry, Patrick G. Northup – 14 July 2015

Kai Markus Schneider, Veerle Bieghs, Felix Heymann, Wei Hu, Daniela Dreymueller, Lijun Liao, Mick Frissen, Andreas Ludwig, Nikolaus Gassler, Oliver Pabst, Eicke Latz, Gernot Sellge, John Penders, Frank Tacke, Christian Trautwein – 14 July 2015 – Nonalcoholic fatty liver disease is seen as the hepatic manifestation of the metabolic syndrome and represents the most common liver disease in Western societies. The G protein–coupled chemokine receptor CX3CR1 plays a central role in several metabolic syndrome–related disease manifestations and is involved in maintaining intestinal homeostasis.

Kathie Béland, Gabriel Marceau, Agathe Labardy, Sara Bourbonnais, Fernando Alvarez – 14 July 2015 – Autoimmune hepatitis (AIH) is known as a T cell–mediated disease. However, AIH patients refractory to conventional treatment have been successfully treated with anti‐CD20‐mediated B‐cell depletion. The aim of this project was to understand the immunological changes underlying the AIH remission caused by B‐cell depletion in an experimental model of AIH.

Ibrahim M. Sayed, Ann‐Sofie Vercouter, Sayed F. Abdelwahab, Koen Vercauteren, Philip Meuleman – 14 July 2015 – Hepatitis E virus (HEV) is yearly responsible for approximately 20 million infections worldwide. Although most infections occur in developing countries, HEV appears to be an emerging problem in several industrialized countries, where it is mostly associated with either traveling to an HEV endemic area or contact with pigs, which represent a major reservoir of HEV.

Hifzur R. Siddique, Douglas E. Feldman, Chia‐Lin Chen, Vasu Punj, Hiroshi Tokumitsu, Keigo Machida – 14 July 2015 – Stem cell populations are maintained through self‐renewing divisions in which one daughter cell commits to a particular fate whereas the other retains the multipotent characteristics of its parent. The NUMB, a tumor suppressor, in conjunction with another tumor‐suppressor protein, p53, preserves this property and acts as a barrier against deregulated expansion of tumor‐associated stem cells.