Impact of body mass index on posttransplant outcomes reexamined
Khurram Bari, Pratima Sharma – 11 August 2015
Research is needed on the difficult‐to‐cure population of hepatitis C virus patients with disability
Viktor Chirikov, Fadia Shaya, C. Daniel Mullins, Susan dosReis, Eberechukwu Onukwugha, Charles Howell – 11 August 2015
Fecal microbiota transplantation in the management of hepatic encephalopathy
Dina Kao, Brandi Roach, Heekuk Park, Naomi Hotte, Karen Madsen, Vince Bain, Puneeta Tandon – 11 August 2015
Fecal microbiota transplantation in the management of hepatic encephalopathy
Dina Kao, Brandi Roach, Heekuk Park, Naomi Hotte, Karen Madsen, Vince Bain, Puneeta Tandon – 11 August 2015
Diabetes and prediabetes in patients with hepatitis B residing in North America
Mandana Khalili, Manuel Lombardero, Raymond T. Chung, Norah A. Terrault, Marc G. Ghany, W. Ray Kim, Daryl Lau, Mauricio Lisker‐Melman, Arun Sanyal, Anna S. Lok, for the HBRN – 8 August 2015 – Diabetes is associated with liver disease progression and increased hepatocellular carcinoma risk, but factors associated with diabetes in patients with chronic hepatitis B virus (HBV) infection in North America are unknown. We aimed to determine factors predictive of diabetes and impaired fasting glucose (IFG) in a large HBV‐infected multiethnic cohort.
Diabetes and prediabetes in patients with hepatitis B residing in North America
Mandana Khalili, Manuel Lombardero, Raymond T. Chung, Norah A. Terrault, Marc G. Ghany, W. Ray Kim, Daryl Lau, Mauricio Lisker‐Melman, Arun Sanyal, Anna S. Lok, for the HBRN – 8 August 2015 – Diabetes is associated with liver disease progression and increased hepatocellular carcinoma risk, but factors associated with diabetes in patients with chronic hepatitis B virus (HBV) infection in North America are unknown. We aimed to determine factors predictive of diabetes and impaired fasting glucose (IFG) in a large HBV‐infected multiethnic cohort.
Sorafenib enriches epithelial cell adhesion molecule–positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2‐AKT cascade
Dong‐Xian Guan, Jie Shi, Yang Zhang, Jiang‐Sha Zhao, Ling‐Yun Long, Tian‐Wei Chen, Er‐Bin Zhang, Yuan‐Yuan Feng, Wen‐Dai Bao, Yue‐Zhen Deng, Lin Qiu, Xue‐Li Zhang, H. Phillip Koeffler, Shu‐qun Cheng, Jing‐Jing Li, Dong Xie – 7 August 2015 – Sorafenib is a specific adenosine triphosphate–competitive RAF inhibitor used as a first‐line treatment of advanced hepatocellular carcinoma (HCC). However, the responses are variable, reflecting heterogeneity of the disease, while the resistance mechanism remains poorly understood.
High‐throughput T‐cell receptor sequencing across chronic liver diseases reveals distinct disease‐associated repertoires
Evaggelia Liaskou, Eva Kristine Klemsdal Henriksen, Kristian Holm, Fatemeh Kaveh, David Hamm, Janine Fear, Marte K. Viken, Johannes Roksund Hov, Espen Melum, Harlan Robins, Johanna Olweus, Tom H. Karlsen, Gideon M. Hirschfield – 7 August 2015 – Hepatic T‐cell infiltrates and a strong genetic human leukocyte antigen association represent characteristic features of various immune‐mediated liver diseases. Conceptually the presence of disease‐associated antigens is predicted to be reflected in T‐cell receptor (TCR) repertoires.
Hepatoma in hepatitis B: Infectious disease or liver disease?
David K. Wong – 7 August 2015
Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune‐mediated hepatitis
Tomoko Fujita, Kitipong Soontrapa, Yoshiya Ito, Keiko Iwaisako, Catharina Sagita Moniaga, Masataka Asagiri, Masataka Majima, Shuh Narumiya – 6 August 2015 – Hepatic stellate cells (HSCs) constitute the liver sinusoid with Kupffer cells and liver sinusoidal endothelial cells. While the sinusoid functions as the gateway to liver inflammation, whether HSCs contribute to liver inflammation and, if so, how they exert such functions remain elusive. Here, we found that mouse as well as human HSCs expressed DP1 receptor for prostaglandin D2 selectively in the liver.