Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice

Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu – 29 February 2016 – Hyperhomocysteinemia (HHcy) is associated with liver diseases such as fatty liver and hepatic fibrosis; however, the underlying mechanism is still largely unknown. The current study aimed to explore the signaling pathway involved in HHcy‐induced hepatic steatosis (HS). C57BL/6 mice were fed a high‐methionine diet (HMD) for 4 and 8 weeks to establish the HHcy mouse model.

A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease

Jagpal Singh Klair, Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine Yates, Aynur Unalp‐Arida, Joel E. Lavine, Jeanne M. Clark, Anna Mae Diehl, Ayako Suzuki, for the Nonalcoholic Steatohepatitis Clinical Research Network – 26 February 2016 – Postmenopausal women with nonalcoholic steatohepatitis are at an increased risk of hepatic fibrosis compared with premenopausal women. Whether duration of estrogen deficiency in postmenopausal state dictates an individual's fibrosis risk remains uninvestigated.

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