Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Xiaofang Sun, Zhanhui Ou, Ruochan Chen, Xiaohua Niu, De Chen, Rui Kang, Daolin Tang – 24 September 2015 – Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐dependent accumulation of lipid reactive oxygen species. However, the molecular mechanisms regulating ferroptosis remain obscure. Here, we report that nuclear factor erythroid 2‐related factor 2 (NRF2) plays a central role in protecting hepatocellular carcinoma (HCC) cells against ferroptosis.

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Karim Gariani, Keir J. Menzies, Dongryeol Ryu, Casey J. Wegner, Xu Wang, Eduardo R. Ropelle, Norman Moullan, Hongbo Zhang, Alessia Perino, Vera Lemos, Bohkyung Kim, Young‐Ki Park, Alessandra Piersigilli, Tho X. Pham, Yue Yang, Chai Siah Ku, Sung I. Koo, Anna Fomitchova, Carlos Cantó, Kristina Schoonjans, Anthony A.

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Karim Gariani, Keir J. Menzies, Dongryeol Ryu, Casey J. Wegner, Xu Wang, Eduardo R. Ropelle, Norman Moullan, Hongbo Zhang, Alessia Perino, Vera Lemos, Bohkyung Kim, Young‐Ki Park, Alessandra Piersigilli, Tho X. Pham, Yue Yang, Chai Siah Ku, Sung I. Koo, Anna Fomitchova, Carlos Cantó, Kristina Schoonjans, Anthony A.

Vasopressin 1a receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats

Guillermo Fernández‐Varo, Denise Oró, Edward Earl Cable, Vedrana Reichenbach, Silvia Carvajal, Bernardino González de la Presa, Kazimierz Wiśniewski, Pere Ginés, Geoffrey Harris, Wladimiro Jiménez – 24 September 2015 – Patients and rats with cirrhosis and ascites have portal hypertension and circulatory dysfunction. Synthetic arginine vasopressin (AVP) receptor agonists able to induce systemic and mesenteric vasoconstriction have shown their usefulness in reducing portal pressure (PP) in this condition.

Predictors of hepatitis B e antigen‐negative hepatitis in chronic hepatitis B virus‐infected patients from childhood to adulthood

Jia‐Feng Wu, Yu‐Chun Chiu, Kai‐Chi Chang, Huey‐Ling Chen, Yen‐Hsuan Ni, Hong‐Yuan Hsu, Mei‐Hwei Chang – 21 September 2015 – Hepatitis B e antigen (HBeAg)‐negative hepatitis is a clinical indicator of poor outcome for chronic hepatitis B viral (HBV) infection. This long‐term prospective cohort study aimed to elucidate the predictors of developing HBeAg‐negative hepatitis in chronic HBV‐infected subjects followed from childhood to adulthood. We followed 434 HBeAg‐positive chronic HBV‐infected patients from a median age of 7.22 years (interquartile range 4.31‐10.21 years).

Targeting the Achilles' heel of adult living donor liver transplant: Corner‐sparing sutures with mucosal eversion technique of biliary anastomosis

Vivek Vij, Kausar Makki, Vishal Kumar Chorasiya, Gaurav Sood, Ashish Singhal, Puneet Dargan – 21 September 2015 – Biliary complications are regarded as the Achilles' heel of liver transplantation, especially for living donor liver transplantation (LDLT) due to smaller, multiple ducts and difficult ductal anatomy. Overall biliary complications reported in most series are between 10% and 30%. This study describes our modified technique of biliary anastomosis and its effects on incidence of biliary complications.

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