A novel objective method for deceased donor and recipient size matching in liver transplantation

Kristopher P. Croome, David D. Lee, Hector Saucedo‐Crespo, Justin M. Burns, Justin H. Nguyen, Dana K. Perry, C. Burcin Taner – 11 September 2015 – Although the consequences of implantation of a large whole liver graft into a small recipient such as compression and compromise of graft perfusion are well known, no accepted measure to aid in donor‐to‐recipient size matching exists.

Primary prophylaxis of variceal bleeding in children and the role of MesoRex Bypass: Summary of the Baveno VI Pediatric Satellite Symposium

Benjamin L. Shneider, Jean de Ville de Goyet, Daniel H. Leung, Anshu Srivastava, Simon C. Ling, Mathieu Duché, Patrick McKiernan, Riccardo Superina, Robert H. Squires, Jaime Bosch, Roberto Groszmann, Shiv K. Sarin, Roberto de Franchis, George V. Mazariegos – 11 September 2015 – Approaches to the management of portal hypertension and variceal hemorrhage in pediatrics remain controversial, in large part because they are not well informed by rigorous clinical studies. Fundamental biological and clinical differences preclude automatic application of approaches used for adults to children.

Conversion of once‐daily extended‐release tacrolimus is safe in stable liver transplant recipients: A randomized prospective study

Jong Man Kim, Choon Hyuck David Kwon, Jae‐Won Joh, Dong Hyun Sinn, Sanghoon Lee, Gyu‐Seong Choi, Suk‐Koo Lee – 11 September 2015 – Simplifying the therapeutic regimen of liver transplantation (LT) recipients may help prevent acute rejection and graft failure. The present study aimed to evaluate the efficacy and safety of conversion from twice‐daily tacrolimus to once‐daily extended‐release tacrolimus under concurrent mycophenolate mofetil therapy in stable LT recipients.

Prognosis of acute variceal bleeding: Is being on beta‐blockers an aggravating factor? A short‐term survival analysis

Andrea Ribeiro de Souza, Vincenzo La Mura, Annalisa Berzigotti, Juan Carlos García‐Pagán, Juan G. Abraldes, Jaime Bosch – 4 September 2015 – Nonselective beta‐blockers (NSBB) are widely used because they have been proved effective in the prophylaxis of acute variceal bleeding (AVB). However, a significant proportion of patients still experience AVB while on treatment with NSBB, and its impact on prognosis of AVB is unknown.

Thrombelastography‐guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial

Lesley De Pietri, Marcello Bianchini, Roberto Montalti, Nicola De Maria, Tommaso Di Maira, Bruno Begliomini, Giorgio Enrico Gerunda, Fabrizio di Benedetto, Guadalupe Garcia‐Tsao, Erica Villa – 4 September 2015 – Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT).

Human immunodeficiency virus and liver disease: An update

Kenneth E. Sherman, Juergen Rockstroh, David Thomas – 4 September 2015 – Human immunodeficiency viral (HIV) infection affects approximately 1.2 million persons in the United States and 35 million worldwide. Progression to advanced liver disease remains a leading cause of death among HIV‐infected persons in the United States and elsewhere. Though mortality from HIV complications has been dramatically reduced wherever effective combination antiretroviral therapy is used, there has been little impact on liver‐related mortality.

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