Functional impairment in older liver transplantation candidates: From the functional assessment in liver transplantation study

Connie W. Wang, Kenneth E. Covinsky, Sandy Feng, Hilary Hayssen, Dorry L. Segev, Jennifer C. Lai – 11 September 2015 – The emerging epidemic of older patients with cirrhosis has led to a sharp increase in the number of ≥65 year olds considering liver transplantation (LT). However, clinicians lack objective measures to risk stratify older patients. We aimed to determine whether the short physical performance battery (SPPB), a well‐validated geriatric measure of physical function, has greater prognostic value in older versus younger LT candidates.

Natural killer cell phenotype modulation and natural killer/T‐cell interplay in nucleos(t)ide analogue‐treated hepatitis e antigen‐negative patients with chronic hepatitis B

Carolina Boni, Pietro Lampertico, Lavinia Talamona, Tiziana Giuberti, Federica Invernizzi, Valeria Barili, Paola Fisicaro, Marzia Rossi, Maria Cristina Cavallo, Andrea Vecchi, Giuseppe Pedrazzi, Arianna Alfieri, Massimo Colombo, Gabriele Missale, Carlo Ferrari – 11 September 2015 – Natural killer (NK) and hepatitis B virus (HBV)‐specific T cells are functionally impaired in chronic hepatitis B (CHB).

Mitogen‐activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial‐mesenchymal transition

Liu‐Xiao Yang, Qiang Gao, Jie‐Yi Shi, Zhi‐Chao Wang, Yong Zhang, Ping‐Ting Gao, Xiao‐Ying Wang, Ying‐Hong Shi, Ai‐Wu Ke, Guo‐Ming Shi, Jia‐Bin Cai, Wei‐Ren Liu, Meng Duan, Ying‐Jun Zhao, Yuan Ji, Dong‐Mei Gao, Kai Zhu, Jian Zhou, Shuang‐Jian Qiu, Ya Cao, Qi‐Qun Tang, Jia Fan – 4 September 2015 – The molecular pathogenesis of intrahepatic cholangiocarcinoma (iCCA) is poorly understood, and its incidence continues to increase worldwide.

Prognosis of acute variceal bleeding: Is being on beta‐blockers an aggravating factor? A short‐term survival analysis

Andrea Ribeiro de Souza, Vincenzo La Mura, Annalisa Berzigotti, Juan Carlos García‐Pagán, Juan G. Abraldes, Jaime Bosch – 4 September 2015 – Nonselective beta‐blockers (NSBB) are widely used because they have been proved effective in the prophylaxis of acute variceal bleeding (AVB). However, a significant proportion of patients still experience AVB while on treatment with NSBB, and its impact on prognosis of AVB is unknown.

Human immunodeficiency virus and liver disease: An update

Kenneth E. Sherman, Juergen Rockstroh, David Thomas – 4 September 2015 – Human immunodeficiency viral (HIV) infection affects approximately 1.2 million persons in the United States and 35 million worldwide. Progression to advanced liver disease remains a leading cause of death among HIV‐infected persons in the United States and elsewhere. Though mortality from HIV complications has been dramatically reduced wherever effective combination antiretroviral therapy is used, there has been little impact on liver‐related mortality.

Subscribe to