Hepatic stellate cells regulate liver immunity to visceral leishmaniasis through P110δ‐dependent induction and expansion of regulatory T cells in mice

Forough Khadem, Xiaoling Gao, Zhirong Mou, Ping Jia, Hesamaldin Movassagh, Chukwunonso Onyilagha, Abdelilah S. Gounni, Matthew C. Wright, Jude E. Uzonna – 20 August 2015 – Visceral leishmaniasis (VL) is associated with severe immune dysfunction and if untreated leads to death. Because the liver is one of the primary target organs in VL, unraveling the mechanisms governing the local hepatic immune response is important for understanding the immunopathogenesis of VL.

Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists

Palak J. Trivedi, Christophe Corpechot, Albert Pares, Gideon M. Hirschfield – 20 August 2015 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent autoimmune cholestatic liver diseases, that disproportionate to their incidence and prevalence, remain very important causes of morbidity and mortality for patients with liver disease.

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