Hepatic stellate cells regulate liver immunity to visceral leishmaniasis through P110δ‐dependent induction and expansion of regulatory T cells in mice

Forough Khadem, Xiaoling Gao, Zhirong Mou, Ping Jia, Hesamaldin Movassagh, Chukwunonso Onyilagha, Abdelilah S. Gounni, Matthew C. Wright, Jude E. Uzonna – 20 August 2015 – Visceral leishmaniasis (VL) is associated with severe immune dysfunction and if untreated leads to death. Because the liver is one of the primary target organs in VL, unraveling the mechanisms governing the local hepatic immune response is important for understanding the immunopathogenesis of VL.

Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists

Palak J. Trivedi, Christophe Corpechot, Albert Pares, Gideon M. Hirschfield – 20 August 2015 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent autoimmune cholestatic liver diseases, that disproportionate to their incidence and prevalence, remain very important causes of morbidity and mortality for patients with liver disease.

Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists

Palak J. Trivedi, Christophe Corpechot, Albert Pares, Gideon M. Hirschfield – 20 August 2015 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent autoimmune cholestatic liver diseases, that disproportionate to their incidence and prevalence, remain very important causes of morbidity and mortality for patients with liver disease.

Outcomes for liver transplant candidates listed with low model for end‐stage liver disease score

Allison J. Kwong, Jennifer C. Lai, Jennifer L. Dodge, John P. Roberts – 20 August 2015 – The Model for End‐Stage Liver Disease (MELD) score, which estimates mortality within 90 days, determines priority for liver transplantation (LT). However, longer‐term outcomes on the wait list for patients who are initially listed with low MELD scores are not well characterized. All adults listed for primary LT at a single, high‐volume center from 2005 to 2012 with an initial laboratory MELD score of 22 or lower were evaluated.

Combined effect of donor and recipient risk on outcome after liver transplantation: Research of the Eurotransplant database

Joris J. Blok, Hein Putter, Xavier Rogiers, Bart van Hoek, Undine Samuel, Jan Ringers, Andries E. Braat, Eurotransplant Liver Intestine Advisory Committee – 20 August 2015 – Recently the Eurotransplant donor risk index (ET‐DRI) was published, a model based on data from the Eurotransplant database that can be used for risk indication of liver donors within the Eurotransplant region. Because outcome after liver transplantation (LT) depends both on donor and recipient risk factors, a combined donor‐recipient model (DRM) would give a more complete picture of the overall risk involved.

Overactivation of the nuclear factor (erythroid‐derived 2)–like 2–antioxidant response element pathway in hepatocytes decreases hepatic ischemia/reperfusion injury in mice

Lung‐Yi Lee, Calvin Harberg, Kristina A. Matkowskyj, Shelly Cook, Drew Roenneburg, Sabine Werner, Jeffrey Johnson, David P. Foley – 18 August 2015 – Hepatic ischemia/reperfusion injury (IRI) is a critical component of hepatic surgery. Oxidative stress has long been implicated as a key player in IRI. In this study, we examine the cell‐specific role of the nuclear factor (erythroid‐derived 2)–like 2 (Nrf2)–antioxidant response element pathway in warm hepatic IRI.

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