Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists

Palak J. Trivedi, Christophe Corpechot, Albert Pares, Gideon M. Hirschfield – 20 August 2015 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent autoimmune cholestatic liver diseases, that disproportionate to their incidence and prevalence, remain very important causes of morbidity and mortality for patients with liver disease.

Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists

Palak J. Trivedi, Christophe Corpechot, Albert Pares, Gideon M. Hirschfield – 20 August 2015 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent autoimmune cholestatic liver diseases, that disproportionate to their incidence and prevalence, remain very important causes of morbidity and mortality for patients with liver disease.

Hepatic stellate cells regulate liver immunity to visceral leishmaniasis through P110δ‐dependent induction and expansion of regulatory T cells in mice

Forough Khadem, Xiaoling Gao, Zhirong Mou, Ping Jia, Hesamaldin Movassagh, Chukwunonso Onyilagha, Abdelilah S. Gounni, Matthew C. Wright, Jude E. Uzonna – 20 August 2015 – Visceral leishmaniasis (VL) is associated with severe immune dysfunction and if untreated leads to death. Because the liver is one of the primary target organs in VL, unraveling the mechanisms governing the local hepatic immune response is important for understanding the immunopathogenesis of VL.

Overactivation of the nuclear factor (erythroid‐derived 2)–like 2–antioxidant response element pathway in hepatocytes decreases hepatic ischemia/reperfusion injury in mice

Lung‐Yi Lee, Calvin Harberg, Kristina A. Matkowskyj, Shelly Cook, Drew Roenneburg, Sabine Werner, Jeffrey Johnson, David P. Foley – 18 August 2015 – Hepatic ischemia/reperfusion injury (IRI) is a critical component of hepatic surgery. Oxidative stress has long been implicated as a key player in IRI. In this study, we examine the cell‐specific role of the nuclear factor (erythroid‐derived 2)–like 2 (Nrf2)–antioxidant response element pathway in warm hepatic IRI.

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