Exendin‐4 attenuates brain death–induced liver damage in the rat

Rodrigo Carlessi, Natalia E. Lemos, Ana L. Dias, Leticia A. Brondani, Jarbas R. Oliveira, Andrea C. Bauer, Cristiane B. Leitão, Daisy Crispim – 3 September 2015 – The majority of liver grafts destined for transplantation originate from brain dead donors. However, significantly better posttransplantation outcomes are achieved when organs from living donors are used, suggesting that brain death (BD) causes irreversible damage to the liver tissue. Recently, glucagon‐like peptide‐1 (GLP1) analogues were shown to possess interesting hepatic protection effects in different liver disease models.

Augmented Wnt signaling as a therapeutic tool to prevent ischemia/reperfusion injury in liver: Preclinical studies in a mouse model

Bowen Liu, Rong Zhang, Guozhong Tao, Nadja Corinna Lehwald, Bo Liu, Yangseok Koh, Karl G. Sylvester – 3 September 2015 – The Wnt signaling pathway has established biological roles in liver development, regeneration, and carcinogenesis. Given the common need for cellular energy utilization in each of these processes, we hypothesized that Wnt signaling would directly regulate hepatocyte mitochondrial function. Mice were engineered to overexpress Wnt1 in hepatocytes under the control of a tetracycline analogue.

Characteristics and outcomes of neutropenia after orthotopic liver transplantation

Basem Alraddadi, Natalie E. Nierenberg, Lori Lyn Price, Jennifer K. L. Chow, Debra D. Poutsiaka, Richard J. Rohrer, Jeffrey T. Cooper, Richard B. Freeman, David R. Snydman – 3 September 2015 – Neutropenia after orthotopic liver transplantation (LT) is relatively common, but the factors associated with its development remain elusive.

Living donor liver transplantation using dual grafts: Experience and lessons learned from cases worldwide

Yinzhe Xu, Hao Chen, Heidi Yeh, Hongguang Wang, Jianjun Leng, Jiahong Dong – 3 September 2015 – In living donor liver transplantation (LDLT), insufficient graft volume could result in small‐for‐size syndrome in recipients, whereas major liver donation predisposes the donor to a high risk of posthepatectomy liver failure. Dual graft LDLT is therefore introduced to obtain combined graft sufficiency. To date, 367 patients have been reported worldwide. We reviewed all the relevant literature, with a special focus on 43 case reports containing enough data to extract and analyze.

Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation

Xian‐Sheng Zhu, Sha‐Sha Wang, Qi Cheng, Chuang‐Wen Ye, Feng Huo, Peng Li – 3 September 2015 – Extracorporeal membrane oxygenation (ECMO) has been used to support brain‐dead donors for liver procurement. This study investigated the potential role of ultrasonographic monitoring of hepatic perfusion as an aid to improve the viability of liver transplants obtained from brain‐dead donors who are supported on ECMO. A total of 40 brain‐dead patients maintained on ECMO served as the study population.

Impact of donor age in liver transplantation from donation after circulatory death donors: A decade of experience at Cleveland Clinic

Daniel J. Firl, Koji Hashimoto, Colin O'Rourke, Teresa Diago‐Uso, Masato Fujiki, Federico N. Aucejo, Cristiano Quintini, Dympna M. Kelly, Charles M. Miller, John J. Fung, Bijan Eghtesad – 3 September 2015 – The use of liver grafts from donation after circulatory death (DCD) donors remains controversial, particularly with donors of advanced age. This retrospective study investigated the impact of donor age in DCD liver transplantation.

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