Primary prophylaxis of variceal bleeding in children and the role of MesoRex Bypass: Summary of the Baveno VI Pediatric Satellite Symposium

Benjamin L. Shneider, Jean de Ville de Goyet, Daniel H. Leung, Anshu Srivastava, Simon C. Ling, Mathieu Duché, Patrick McKiernan, Riccardo Superina, Robert H. Squires, Jaime Bosch, Roberto Groszmann, Shiv K. Sarin, Roberto de Franchis, George V. Mazariegos – 11 September 2015 – Approaches to the management of portal hypertension and variceal hemorrhage in pediatrics remain controversial, in large part because they are not well informed by rigorous clinical studies. Fundamental biological and clinical differences preclude automatic application of approaches used for adults to children.

A novel objective method for deceased donor and recipient size matching in liver transplantation

Kristopher P. Croome, David D. Lee, Hector Saucedo‐Crespo, Justin M. Burns, Justin H. Nguyen, Dana K. Perry, C. Burcin Taner – 11 September 2015 – Although the consequences of implantation of a large whole liver graft into a small recipient such as compression and compromise of graft perfusion are well known, no accepted measure to aid in donor‐to‐recipient size matching exists.

Excellent outcomes of liver transplantation using severely steatotic grafts from brain‐dead donors

Tiffany C. L. Wong, James Y. Y. Fung, Kenneth S. H. Chok, Tan To Cheung, Albert C. Y. Chan, William W. Sharr, Wing Chiu Dai, See Ching Chan, Chung Mau Lo – 11 September 2015 – Liver grafts with macrovesicular steatosis of >60% are considered unsuitable for deceased donor liver transplantation (DDLT) because of the unacceptably high risk of primary nonfunction (PNF) and graft loss. This study reports our experience in using such grafts from brain‐dead donors. Prospectively collected data of DDLT recipient outcomes from 1991 to 2013 were retrospectively analyzed.

Functional impairment in older liver transplantation candidates: From the functional assessment in liver transplantation study

Connie W. Wang, Kenneth E. Covinsky, Sandy Feng, Hilary Hayssen, Dorry L. Segev, Jennifer C. Lai – 11 September 2015 – The emerging epidemic of older patients with cirrhosis has led to a sharp increase in the number of ≥65 year olds considering liver transplantation (LT). However, clinicians lack objective measures to risk stratify older patients. We aimed to determine whether the short physical performance battery (SPPB), a well‐validated geriatric measure of physical function, has greater prognostic value in older versus younger LT candidates.

Natural killer cell phenotype modulation and natural killer/T‐cell interplay in nucleos(t)ide analogue‐treated hepatitis e antigen‐negative patients with chronic hepatitis B

Carolina Boni, Pietro Lampertico, Lavinia Talamona, Tiziana Giuberti, Federica Invernizzi, Valeria Barili, Paola Fisicaro, Marzia Rossi, Maria Cristina Cavallo, Andrea Vecchi, Giuseppe Pedrazzi, Arianna Alfieri, Massimo Colombo, Gabriele Missale, Carlo Ferrari – 11 September 2015 – Natural killer (NK) and hepatitis B virus (HBV)‐specific T cells are functionally impaired in chronic hepatitis B (CHB).

Mitogen‐activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial‐mesenchymal transition

Liu‐Xiao Yang, Qiang Gao, Jie‐Yi Shi, Zhi‐Chao Wang, Yong Zhang, Ping‐Ting Gao, Xiao‐Ying Wang, Ying‐Hong Shi, Ai‐Wu Ke, Guo‐Ming Shi, Jia‐Bin Cai, Wei‐Ren Liu, Meng Duan, Ying‐Jun Zhao, Yuan Ji, Dong‐Mei Gao, Kai Zhu, Jian Zhou, Shuang‐Jian Qiu, Ya Cao, Qi‐Qun Tang, Jia Fan – 4 September 2015 – The molecular pathogenesis of intrahepatic cholangiocarcinoma (iCCA) is poorly understood, and its incidence continues to increase worldwide.

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