Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Anne‐Marieke Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan Born, Adriaan Georgius Holleboom – 4 November 2022 – Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations. Therefore, we studied prevalence and ethnic differences in NAFLD with NITs in the multi‐ethnic HEalthy Life In an Urban Setting (HELIUS) cohort.

Leveraging corona virus disease 2019 vaccination to promote hepatitis C screening

Aaron Vanderhoff, David Smookler, Mia J. Biondi, Scott Enman, Tintin Fuliang, Sana Mahmood, Agustina Crespi, Maria Marquez, Rafique Van Uum, Lucy You, Brett Wolfson‐Stofko, Renee Logan, Erin LeDrew, Hemant Shah, Harry Janssen, Camelia Capraru, Elisa Venier, Jordan J. Feld – 2 November 2022 – Health care initiatives, such as hepatitis C virus (HCV) screening, have been greatly overshadowed by the corona virus disease 2019 (COVID‐19) pandemic. However, COVID‐19 vaccination programs also provide an opportunity to engage with a high volume of people in a health care setting.

NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression

Ya‐Chin Wang, Ming‐Chao Tsai, Yaw‐Sen Chen, Pei‐Min Hsieh, Chao‐Ming Hung, Hung‐Yu Lin, Yao‐Chun Hsu, Jen‐Hao Yeh, Pojen Hsiao, Yu‐Cheih Su, Ching‐Hou Ma, Chih‐Yuan Lee, Chih‐Che Lin, Chih‐Wen Shu, Yu‐Chan Li, Mei‐Hsing Tsai, James Yu Lin, Wei‐Hao Peng, Ming‐Lung Yu, Chih‐Wen Lin – 1 November 2022 – Hepatocellular carcinoma (HCC) is a highly invasive malignancy. Recently, GATOR1 (Gap Activity TOward Rags 1) complexes have been shown to play an important role in regulating tumor growth. NPRL2 is a critical component of the GATOR1 complex.

A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance

Martijn P. D. Haring, Arthur K. E. Elfrink, Christiaan A. J. Oudmaijer, Paul C. M. Andel, Alicia Furumaya, Nenke Jong, Colin J. J. M. Willems, Thijs Huits, Julie M. L. Sijmons, Eric J. T. Belt, Koop Bosscha, Esther C. J. Consten, Mariëlle M. E. Coolsen, Peter Duijvendijk, Joris I. Erdmann, Paul Gobardhan, Robbert J. Haas, Tjarda Heek, Hwai‐Ding Lam, Wouter K. G. Leclercq, Mike S. L. Liem, Hendrik A. Marsman, Gijs A. Patijn, Türkan Terkivatan, Babs M. Zonderhuis, Izaak Quintus Molenaar, Wouter W. Riele, Jeroen Hagendoorn, Alexander F. M. Schaapherder, Jan N. M. IJzermans, Carlijn I.

Factors associated with cardiovascular events after simultaneous liver–kidney transplant from the US Multicenter Simultaneous Liver–Kidney Transplant Consortium

Jennifer Jo, Gonzalo Crespo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min Zhang, John Magee, Pranab Barman, Yuval A. Patel, Aaron Schluger, Kara Walters, Scott Biggins, Natalia Filipek, Giuseppe Cullaro, Randi Wong, Jennifer C. Lai, Gabriel J. Perreault, Elizabeth C. Verna, Pratima Sharma, Lisa B. VanWagner – 25 October 2022 – Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown.

Robert K. Ockner, MD, FAASLD

Robert K. Ockner, MD, FAASLD

It is with great sadness that we announce the death after a brief illness, at the age of 86, of our esteemed colleague, and Past President of the AASLD, Robert (Bob) Keith Ockner, MD, Emeritus Professor of Medicine in the Division of Gastroenterology at UCSF. Bob passed away on September 26 after a brief illness . 

Bob was born in New Kensington, Pennsylvania in 1936. He graduated from Pomona College in 1957 and received his MD from Harvard in 1961. While a medical student, he worked with Rudi Schmid, MD, PhD, future chief of the UCSF Division of Gastroenterology and dean of the UCSF School of Medicine, on a project investigating the occurrence of porphyria in humans and rodents from hexachlorobenzene poisoning. That work led to Bob’s first publication in Nature. 

Bob completed residency in internal medicine at Harvard Medical Services, Boston City Hospital and a fellowship in Gastroenterology at the National Institutes of Arthritis and Metabolic Diseases, studying lipid metabolism under the preceptorship of Kurt Isselbacher, MD. In 1968, Schmid recruited Bob to the GI faculty at UCSF. He rapidly rose to the rank of full professor. He served as the chief of the division from 1983 until 1990, a period of growth and innovation that included the establishment of UCSF’s liver transplant program. While at UCSF, Bob mentored many future leaders in gastroenterology and hepatology. All recall his understated qualities of patience, kindness, thoughtfulness, and supportive guidance.

Although an astute, dedicated and compassionate clinician and educator, Bob’s main passion lay in scientific inquiry and writing. His research resulted in 94 publications focused on the field of lipid and lipoprotein metabolism. Among his most notable discoveries were the intracellular fatty acid binding proteins in the intestine. Between 1983 and 1998, Bob served as the director of the NIH-funded Liver Center at UCSF. He was elected president of the American Association for the Study of Liver Diseases in 1984. 

Bob also served as Editor-in-Chief (1981-86) of Gastroenterology, the field’s major journal, and served as Consulting Editor for the Digestive Diseases Section in Cecil Textbook of Medicine, 19th and 20th Editions. Brimming with ideas, deep knowledge, and a unique appreciation of the influence of cellular metabolic pathways on disease processes, Bob closed his research career with the writing and publication of a 2004 monograph (Integration of Metabolism, Energetics, and Signal Transduction: Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease) that presented beautifully reasoned hypotheses concerning the pathogenesis of several important diseases.

Among his many talents, Bob was a fine performer on the cello and a member of several community orchestras. It was his love of music that brought him to his second wife, Elaine Fishman Lang, a professional pianist and composer. They often performed together in retirement centers and for friends.

Bob is survived by his wife, Elaine, by three sons, Jim, Matt and Peter, their wives Gillian, Kassy and Paula, and 8 grandchildren.
 

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