Michael D. Aleo, Yi Luo, Rachel Swiss, Paul D. Bonin, David M. Potter, Yvonne Will – 6 May 2014 – Drug‐induced liver injury (DILI) accounts for 20‐40% of all instances of clinical hepatic failure and is a common reason for withdrawal of an approved drug or discontinuation of a potentially new drug from clinical/nonclinical development. Numerous individual risk factors contribute to the susceptibility to human DILI and its severity that are either compound‐ and/or patient‐specific.

Juliane Winkler, Alessandro Ori, Kerstin Holzer, Carsten Sticht, Daniel Dauch, Eva Maria Eiteneuer, Federico Pinna, Robert Geffers, Volker Ehemann, Amparo Andres‐Pons, Kai Breuhahn, Thomas Longerich, Justo Lorenzo Bermejo, Norbert Gretz, Lars Zender, Peter Schirmacher, Martin Beck, Stephan Singer – 6 May 2014 – Proteins of the karyopherin superfamily including importins and exportins represent an essential part of the nucleocytoplasmic transport machinery. However, the functional relevance and regulation of karyopherins in hepatocellular carcinoma (HCC) is poorly understood.

Bilal Hameed, Neil Mehta, Gonzalo Sapisochin, John P. Roberts, Francis Y. Yao – 6 May 2014 – Serum alpha‐fetoprotein (AFP) has been increasingly recognized as a marker for a poor prognosis after liver transplantation (LT) for hepatocellular carcinoma (HCC). Many published reports, however, have included a large proportion of patients with HCC beyond the Milan criteria, and the effects of incorporating AFP as an exclusion criterion for LT remain unclear.

Jin‐Zhong Dong, Li‐Ping Wang, Sai‐Nan Zhang, Zhuo‐Lin Zou, Ming‐Qin Lu – 6 May 2014

Bryan C. Fuchs, Yujin Hoshida, Kenneth K. Tanabe – 5 May 2014

Nirmala Mavila, David James, Pranavkumar Shivakumar, Marie V. Nguyen, Sarah Utley, Katrina Mak, Allison Wu, Shengmei Zhou, Larry Wang, Christopher Vendyres, Megan Groff, Kinji Asahina, Kasper S. Wang – 3 May 2014 – Biliary atresia (BA), the most common cause of end‐stage liver disease and the leading indication for pediatric liver transplantation, is associated with intrahepatic ductular reactions within regions of rapidly expanding periportal biliary fibrosis.

Mariya L. Samoylova, Jennifer L. Dodge, Francis Y. Yao, John Paul Roberts – 3 May 2014 – In the United States, there are significant geographic disparities in the time to transplantation for patients with hepatocellular carcinoma (HCC); it is possible that rapid transplantation contributes to higher rates of posttransplant HCC recurrence because there is insufficient time for the tumor biology to manifest. In this study, we compared HCC recurrence in rapid transplant patients and their slower transplant counterparts.

Sung‐Min Ahn, Se Jin Jang, Ju Hyun Shim, Deokhoon Kim, Seung‐Mo Hong, Chang Ohk Sung, Daehyun Baek, Farhan Haq, Adnan Ahmad Ansari, Sun Young Lee, Sung‐Min Chun, Seongmin Choi, Hyun‐Jeung Choi, Jongkyu Kim, Sukjun Kim, Shin Hwang, Young‐Joo Lee, Jong‐eun Lee, Wang‐rim Jung, Hye Yoon Jang, Eunho Yang, Wing‐Kin Sung, Nikki P.

Michael H. Levy, Sarah Larney – 3 May 2014

Koen Vercauteren, Naomi Van Den Eede, Ahmed Atef Mesalam, Sandrine Belouzard, Maria Teresa Catanese, Dorothea Bankwitz, Flossie Wong‐Staal, Riccardo Cortese, Jean Dubuisson, Charles M. Rice, Thomas Pietschmann, Geert Leroux‐Roels, Alfredo Nicosia, Philip Meuleman – 3 May 2014 – Hepatitis C virus (HCV)‐induced endstage liver disease is currently a major indication for liver transplantation. After transplantation the donor liver inevitably becomes infected with the circulating virus.