Peroxisome proliferator‐activated receptor α activates human multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion

Nisanne S. Ghonem, Meenakshisundaram Ananthanarayanan, Carol J. Soroka, James L. Boyer – 12 October 2013 – Multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Clinically, mutations and partial deficiencies in MDR3 result in cholestatic liver injury. Thus, MDR3 is a potential therapeutic target for cholestatic liver disease. Fenofibrate is a peroxisome proliferator‐activated receptor (PPAR) α ligand that has antiinflammatory actions and regulates bile acid detoxification.

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