Transplant plenary I
15 October 2013
15 October 2013
15 October 2013
15 October 2013
Lars P. Bechmann, Ali Canbay – 12 October 2013
Silvia Sookoian, Carlos J. Pirola – 12 October 2013
Mary K. Rude, Rao Watson, Jeffrey S. Crippin – 12 October 2013
Mary K. Rude, Rao Watson, Jeffrey S. Crippin – 12 October 2013
Nisanne S. Ghonem, Meenakshisundaram Ananthanarayanan, Carol J. Soroka, James L. Boyer – 12 October 2013 – Multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Clinically, mutations and partial deficiencies in MDR3 result in cholestatic liver injury. Thus, MDR3 is a potential therapeutic target for cholestatic liver disease. Fenofibrate is a peroxisome proliferator‐activated receptor (PPAR) α ligand that has antiinflammatory actions and regulates bile acid detoxification.