Serum bile acids in intrahepatic cholestasis of pregnancy: Not just a diagnostic test
Laura N. Bull, Juan Vargas – 9 October 2013
A new role for IKK‐α in hepatitis C virus‐induced lipogenesis
Mark W. Douglas, Saeed Esmaili, Jacob George – 9 October 2013
An effective interferon‐gamma‐mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus‐positive patients
Pavlos Kokordelis, Benjamin Krämer, Christian Körner, Christoph Boesecke, Esther Voigt, Patrick Ingiliz, Andreas Glässner, Marianne Eisenhardt, Franziska Wolter, Dominik Kaczmarek, Hans Dieter Nischalke, Jürgen K. Rockstroh, Ulrich Spengler, Jacob Nattermann – 8 October 2013 – Hepatitis C virus (HCV) coinfection is an increasing health problem in human immunodeficiency virus‐positive (HIV+) individuals. However, a considerable proportion of HIV+ patients manage to overcome acute hepatitis C (AHC) spontaneously.
Bile acids reach out to the spinal cord: New insights to the pathogenesis of itch and analgesia in cholestatic liver disease
Paul A. Dawson, Saul J. Karpen – 8 October 2013
Hepatic interferon‐stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin‐28B genotypes
Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Akito Sakai, Rika Horii, Kuniaki Arai, Tatsuya Yamashita, Yoshio Sakai, Taro Yamashita, Hikari Okada, Kazuhisa Murai, Mikiko Nakamura, Eishiro Mizukoshi, Shuichi Kaneko – 8 October 2013 – Pretreatment up‐regulation of hepatic interferon (IFN)‐stimulated genes (ISGs) has a stronger association with the treatment‐resistant interleukin (IL)28B minor genotype (MI; TG/GG at rs8099917) than with the treatment‐sensitive IL28B major genotype (MA; TT at rs8099917).
Pharmacological inhibition of the chemokine C‐C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly‐6C+ macrophage infiltration in mice
Christer Baeck, Xiao Wei, Matthias Bartneck, Viktor Fech, Felix Heymann, Nikolaus Gassler, Kanishka Hittatiya, Dirk Eulberg, Tom Luedde, Christian Trautwein, Frank Tacke – 8 October 2013 – Macrophages constitute a major proinflammatory component during chronic liver diseases and are considered a key factor in promoting hepatic fibrosis. However, there is increasing evidence that distinct monocyte and macrophage subsets exert critical functions in regression from organ fibrosis as well.
Transplanting a fibrogenic microbiota
Bernd Schnabl – 8 October 2013
Hepatitis C genotype 1 virus with low viral load and rapid virologic response to peginterferon/ribavirin obviates a protease inhibitor
Alan S. Wang, Ruth M. Pfeiffer, Timothy R. Morgan, Thomas R. O'Brien – 7 October 2013
Reply
Tetsuya Hosaka, Fumitaka Suzuki, Hiromitsu Kumada – 7 October 2013
Tri‐iodothyronine induces hepatocyte proliferation by protein kinase a‐dependent β‐catenin activation in rodents
Maura Fanti, Sucha Singh, Giovanna M. Ledda‐Columbano, Amedeo Columbano, Satdarshan P. Monga – 7 October 2013 – Thyroid hormone (T3), like many other ligands of the steroid/thyroid hormone nuclear receptor superfamily, is a strong inducer of liver cell proliferation in rats and mice. However, the molecular basis of its mitogenic activity, which is currently unknown, must be elucidated if its use in hepatic regenerative medicine is to be considered. F‐344 rats or C57BL/6 mice were fed a diet containing T3 for 2‐7 days.