Theodore H. Welling, Mary Feng, Shanshan Wan, Sin Ye Hwang, Michael L. Volk, Theodore S. Lawrence, Mark M. Zalupski, Christopher J. Sonnenday – 1 October 2013 – Hilar cholangiocarcinoma (CCA) is a difficult malignancy to treat surgically because of its anatomical location and its frequent association with primary sclerosing cholangitis. Neoadjuvant chemoradiotherapy followed by liver transplantation in lymph node–negative patients has been advanced by select liver transplant centers for the treatment of patients with unresectable disease.

Ralf Bahde, Sorabh Kapoor, Preeti Viswanathan, Hans‐Ullrich Spiegel, Sanjeev Gupta – 1 October 2013 – Cell transplantation‐induced hepatic ischemia and recruitment of vasoconstrictors (e.g., endothelin‐1; Edn1) leads to clearance of transplanted cells and poses problems for liver repopulation. Therefore, we determined whether darusentan (DAR), which potently blocks Edn1 receptor type A, could benefit cell engraftment. We transplanted primary F344 rat hepatocytes with or without DAR in dipeptidyl peptidase IV–deficient rats.

Winston Dunn, Maura O'Neil, Jie Zhao, Chuang Hong Wu, Benjamin Roberts, Shweta Chakraborty, Craig Sherman, Brandy Weaver, Ryan Taylor, Jody Olson, Mojtaba Olyaee, Richard Gilroy, Timothy Schmitt, Yu‐Jui Yvonne Wan, Steven A. Weinman – 1 October 2013 – The rs738409 G>C single nucleotide polymorphism occurring in the patatin‐like phospholipase 3 gene has been identified as a novel genetic marker for hepatic steatosis. Recent studies also associated rs738409 with fibrosis in hepatitis C (HCV).

Martina Buck, Guadalupe Garcia‐Tsao, Roberto J. Groszmann, Caitlin Stalling, Norman D. Grace, Andrew K. Burroughs, David Patch, Daniel S. Matloff, Paul Clopton, Mario Chojkier – 1 October 2013 – The rationale for screening inflammatory serum biomarkers of the hepatic vein pressure gradient (HVPG) is based on the fact that portal hypertension is pathogenically related to liver injury and fibrosis, and that in turn these are associated with the activation of inflammatory pathways.

1 October 2013

1 October 2013

John P. Rice, Jens Eickhoff, Rashmi Agni, Aiman Ghufran, Rinjal Brahmbhatt, Michael R. Lucey – 1 October 2013 – In patients who undergo liver transplantation for alcoholic liver disease (ALD), alcohol relapse is common. A return to abusive or excessive drinking likely decreases overall survival; however, the effects of alcohol use on allograft outcomes and histopathology are less well defined. We reviewed all cases of liver transplantation with ALD as an indication between January 1, 1995 and December 31, 2007.

Xin‐An Wang, Ran Zhang, Zhi‐Gang She, Xiao‐Fei Zhang, Ding‐Sheng Jiang, Tao Wang, Lu Gao, Wei Deng, Shu‐Min Zhang, Li‐Hua Zhu, Sen Guo, Ke Chen, Xiao‐Dong Zhang, De‐Pei Liu, Hongliang Li – 1 October 2013 – Obesity and related metabolic diseases associated with chronic low‐grade inflammation greatly compromise human health. Previous observations on the roles of interferon regulatory factors (IRFs) in the regulation of metabolism prompted investigation of the involvement of a key family member, IRF3, in metabolic disorders.

Tingting Li, Shaomei Zhu, Lifang Shuai, Yuxia Xu, Sen Yin, Yixin Bian, Yuanzhan Wang, Bingfeng Zuo, Wenjing Wang, Shuoxian Zhao, Ling Zhang, Jingang Zhang, George F. Gao, Jean‐Pierre Allain, Chengyao Li – 1 October 2013 – The development of vaccination and novel therapy for hepatitis C virus (HCV) has been hampered by the lack of suitable small‐animal models. GB virus B (GBV‐B), closely related to HCV, causes viral hepatitis in common marmosets (Callithrix jacchue jacchus) and might represent an attractive surrogate model for HCV infection.

Antonio Sica, Pietro Invernizzi, Alberto Mantovani – 1 October 2013 – Resident and recruited macrophages are key players in the homeostatic function of the liver and in its response to tissue damage. In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2‐like activation states. These are extremes of a spectrum in a universe of activation states. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of mononuclear phagocytes.