Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta‐analysis of individual participant data

Eric Trépo, Pierre Nahon, Gianluca Bontempi, Luca Valenti, Edmondo Falleti, Hans‐Dieter Nischalke, Samia Hamza, Stefano Ginanni Corradini, Maria Antonella Burza, Erwan Guyot, Benedetta Donati, Ulrich Spengler, Patrick Hillon, Pierluigi Toniutto, Jean Henrion, Denis Franchimont, Jacques Devière, Philippe Mathurin, Christophe Moreno, Stefano Romeo, Pierre Deltenre – 1 October 2013 – The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several clinical factors have been identified, many individuals never develop HCC, suggesting a genetic susceptibility.

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource

Donald B. Smith, Jens Bukh, Carla Kuiken, A. Scott Muerhoff, Charles M. Rice, Jack T. Stapleton, Peter Simmonds – 1 October 2013 – The 2005 consensus proposal for the classification of hepatitis C virus (HCV) presented an agreed and uniform nomenclature for HCV variants and the criteria for their assignment into genotypes and subtypes. Since its publication, the available dataset of HCV sequences has vastly expanded through advancement in nucleotide sequencing technologies and an increasing focus on the role of HCV genetic variation in disease and treatment outcomes.

Liver regeneration by stem/progenitor cells

Tohru Itoh, Atsushi Miyajima – 1 October 2013 – The liver is renowned for its strong, robust regenerative capacity, employing different modes of regeneration according to type and extent of injury. The process of compensatory hypertrophy of the liver upon partial hepatectomy has been standing as a classical model for studying organ regeneration in mammals and a subject of exhaustive analyses. Meanwhile, in view of the physiological relevance for many of the human liver pathologies induced upon toxic insults or hepatitis, other injury models have recently drawn increasing attention.

Leukocyte cell‐derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

Chi‐Kuan Chen, Ching‐Yao Yang, Kuo‐Tai Hua, Ming‐Chih Ho, Gunnar Johansson, Yung‐Ming Jeng, Chiung‐Nien Chen, Min‐Wei Chen, Wei‐Jiunn Lee, Jen‐Liang Su, Tsung‐Ching Lai, Chi‐Chi Chou, Bing‐Ching Ho, Chuan‐Fa Chang, Po‐Huang Lee, King‐Jen Chang, Michael Hsiao, Ming‐Tsan Lin, Min‐Liang Kuo – 1 October 2013 – Leukocyte cell‐derived chemotoxin 2 (LECT2) has been shown to act as a tumor suppressor in hepatocellular carcinoma (HCC). However, the underlying mechanism has not yet been completely defined.

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

Salvatore Sutti, Aastha Jindal, Irene Locatelli, Marco Vacchiano, Luca Gigliotti, Cristina Bozzola, Emanuele Albano – 1 October 2013 – Previous studies have shown that human nonalcoholic steatohepatitis (NASH) is often associated with the presence of circulating antibodies against protein adducted by lipid peroxidation products. Here we used the methionine‐choline deficient (MCD) model of NASH to characterize the possible involvement of adaptive immunity in NASH.

Role of immunosuppression in post–endoscopic retrograde cholangiopancreatography pancreatitis after liver transplantation: A retrospective analysis

Ryan Law, Carlos Leal, Barham Abu Dayyeh, Michael D. Leise, Domingo Balderramo, Todd H. Baron, Andres Cardenas – 1 October 2013 – Endoscopic retrograde cholangiopancreatography (ERCP) is frequently used for diagnosis and therapeutic interventions in recipients of liver transplantation (LT) who develop biliary complications. Post–endoscopic retrograde cholangiopancreatography acute pancreatitis (PEP) is the most common major adverse event after ERCP; however, the frequency of PEP in LT recipients is not well established.

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