Creatinine‐ versus cystatine C‐based equations in assessing the renal function of candidates for liver transplantation with cirrhosis

Vandréa De Souza, Aoumeur Hadj‐Aissa, Olga Dolomanova, Muriel Rabilloud, Nicolas Rognant, Sandrine Lemoine, Sylvie Radenne, Jérôme Dumortier, Colette Chapuis‐Cellier, Françoise Beyerle, Chantal Bon, Jean Iwaz, Luciano Selistre, Laurence Dubourg – 9 October 2013 – Renal dysfunction is frequent in liver cirrhosis and is a strong prognostic predictor of orthotopic liver transplantation (OLT) outcome. Therefore, an accurate evaluation of the glomerular filtration rate (GFR) is crucial in pre‐OLT patients.

Diagnostic accuracy of 18F‐methylcholine positron emission tomography/computed tomography for intra‐ and extrahepatic hepatocellular carcinoma

Matthanja Bieze, Heinz‐Josef Klümpen, Joanne Verheij, Ulrich Beuers, Saffire S.K.S. Phoa, Thomas M. van Gulik, Roelof J. Bennink – 9 October 2013 – Diagnosis of hepatocellular carcinoma (HCC) primarily involves imaging. The aim of this study was to assess the accuracy of 18F‐fluorocholine (18F‐FCH) positron emission tomography (PET) for detection of HCC and evaluation of extent of disease. Patients with HCC >1 cm were included between 2009 and July 2011, and follow‐up closed in February 2013.

Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Yasuhito Arai, Yasushi Totoki, Fumie Hosoda, Tomoki Shirota, Natsuko Hama, Hiromi Nakamura, Hidenori Ojima, Koh Furuta, Kazuaki Shimada, Takuji Okusaka, Tomoo Kosuge, Tatsuhiro Shibata – 9 October 2013 – Cholangiocarcinoma is an intractable cancer, with limited therapeutic options, in which the molecular mechanisms underlying tumor development remain poorly understood. Identification of a novel driver oncogene and applying it to targeted therapies for molecularly defined cancers might lead to improvements in the outcome of patients.

Pharmacological inhibition of the chemokine C‐C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly‐6C+ macrophage infiltration in mice

Christer Baeck, Xiao Wei, Matthias Bartneck, Viktor Fech, Felix Heymann, Nikolaus Gassler, Kanishka Hittatiya, Dirk Eulberg, Tom Luedde, Christian Trautwein, Frank Tacke – 8 October 2013 – Macrophages constitute a major proinflammatory component during chronic liver diseases and are considered a key factor in promoting hepatic fibrosis. However, there is increasing evidence that distinct monocyte and macrophage subsets exert critical functions in regression from organ fibrosis as well.

Hepatic interferon‐stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin‐28B genotypes

Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Akito Sakai, Rika Horii, Kuniaki Arai, Tatsuya Yamashita, Yoshio Sakai, Taro Yamashita, Hikari Okada, Kazuhisa Murai, Mikiko Nakamura, Eishiro Mizukoshi, Shuichi Kaneko – 8 October 2013 – Pretreatment up‐regulation of hepatic interferon (IFN)‐stimulated genes (ISGs) has a stronger association with the treatment‐resistant interleukin (IL)28B minor genotype (MI; TG/GG at rs8099917) than with the treatment‐sensitive IL28B major genotype (MA; TT at rs8099917).

An effective interferon‐gamma‐mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus‐positive patients

Pavlos Kokordelis, Benjamin Krämer, Christian Körner, Christoph Boesecke, Esther Voigt, Patrick Ingiliz, Andreas Glässner, Marianne Eisenhardt, Franziska Wolter, Dominik Kaczmarek, Hans Dieter Nischalke, Jürgen K. Rockstroh, Ulrich Spengler, Jacob Nattermann – 8 October 2013 – Hepatitis C virus (HCV) coinfection is an increasing health problem in human immunodeficiency virus‐positive (HIV+) individuals. However, a considerable proportion of HIV+ patients manage to overcome acute hepatitis C (AHC) spontaneously.

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