Spectrum of statin hepatotoxicity: Experience of the drug‐induced liver injury network

Mark W. Russo, Jay H. Hoofnagle, Jiezhun Gu, Robert J. Fontana, Huiman Barnhart, David E. Kleiner, Naga Chalasani, Herbert L. Bonkovsky – 2 April 2014 – The HMG‐CoA reductase inhibitors (statins) are widely prescribed for patients with hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases arise in up to 3% of treated patients, but clinically apparent drug‐induced liver injury is rare. The aim of this study is to report the presenting features and outcomes of 22 patients with clinically apparent liver injury due to statins.

Assessment of alcohol consumption in liver transplant candidates and recipients: The best combination of the tools available

Salvatore Piano, Lucio Marchioro, Elisabetta Gola, Silvia Rosi, Filippo Morando, Marta Cavallin, Antonietta Sticca, Silvano Fasolato, Giovanni Forza, Anna Chiara Frigo, Mario Plebani, Giacomo Zanus, Umberto Cillo, Angelo Gatta, Paolo Angeli – 2 April 2014 – The detection of alcohol consumption in liver transplant candidates (LTCs) and liver transplant recipients (LTRs) is required to enable a proper assessment of transplant eligibility and early management of alcohol relapse, respectively.

Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events

Kymberly D. Watt, Chun Fan, Terry Therneau, Julie K. Heimbach, Eric C. Seaberg, Michael R. Charlton – 2 April 2014 – In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. The effects of liver transplantation (LT) on serum adipokine levels and their association with post‐LT CV disease have not been studied.

Decision making in liver transplantation—Limited application of the liver donor risk index

Leslie Mataya, Andrew Aronsohn, J. Richard Thistlethwaite, Lainie Friedman Ross – 1 April 2014 – The liver donor risk index (LDRI), originally developed in 2006 by Feng et al. and since modified, is a method of evaluating liver grafts from deceased donors through the determination of the relative risk of graft failure after transplantation. Online and paper surveys about attitudes and practices regarding decision making in liver transplantation and the role of the LDRI were sent to liver transplant physicians.

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