Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
Salvatore Sutti, Aastha Jindal, Irene Locatelli, Marco Vacchiano, Luca Gigliotti, Cristina Bozzola, Emanuele Albano – 1 October 2013 – Previous studies have shown that human nonalcoholic steatohepatitis (NASH) is often associated with the presence of circulating antibodies against protein adducted by lipid peroxidation products. Here we used the methionine‐choline deficient (MCD) model of NASH to characterize the possible involvement of adaptive immunity in NASH.