Xiongxiong Pan, Worapot Apinyachon, Wei Xia, Johnny C. Hong, Ronald W. Busuttil, Randolph H. Steadman, Victor W. Xia – 8 April 2014 – Donation after cardiac death (DCD) is an important source for expanding the donor pool for liver transplantation (LT). Although the long‐term outcomes of LT using DCD grafts have been extensively studied, perioperative complications related to DCD grafts are rarely reported. The aim of this study was to determine whether DCD grafts were associated with a higher incidence of postreperfusion complications and worse outcomes in adult LT patients.

Lei Gao, Yingchun Zhou, Weichao Zhong, Xiaohua Zhao, Chun Chen, Xingmiao Chen, Yong Gu, Jianping Chen, Zhiping Lv, Jiangang Shen – 8 April 2014 – Caveolin‐1 (Cav‐1) is known to participate in many diseases, but its roles in alcoholic liver injury remain unknown. In the present study, we aimed to explore the roles of Cav‐1 in protecting hepatocytes from ethanol‐mediated nitrosative injury.

Zobair M. Younossi, Maria Stepanova, Fatema Nader, Ira M. Jacobson, Ed Gane, David Nelson, Eric Lawitz, Sharon L. Hunt – 8 April 2014 – Whether the presence of cirrhosis influences patient‐reported outcomes (PROs), including health‐related quality of life, during treatment with newly available anti‐HCV (hepatitis C virus) regimens is unclear. Our aim was to assess the association of cirrhosis with PROs in patients treated with sofosbuvir (SOF)‐containing regimens.

Nicola Oehler, Tassilo Volz, Oliver D. Bhadra, Janine Kah, Lena Allweiss, Katja Giersch, Jeanette Bierwolf, Kristoffer Riecken, Jörg M. Pollok, Ansgar W. Lohse, Boris Fehse, Joerg Petersen, Stephan Urban, Marc Lütgehetmann, Joerg Heeren, Maura Dandri – 8 April 2014 – Chronic hepatitis B virus (HBV) infection has been associated with alterations in lipid metabolism. Moreover, the Na+‐taurocholate cotransporting polypeptide (NTCP), responsible for bile acid (BA) uptake into hepatocytes, was identified as the functional cellular receptor mediating HBV entry.

Amy Gallo, Carlos O. Esquivel – 8 April 2014

Min‐Jun Wang, Fei Chen, Jian‐Xiu Li, Chang‐Cheng Liu, Hai‐Bin Zhang, Yong Xia, Bing Yu, Pu You, Dao Xiang, Lian Lu, Hao Yao, Uyunbilig Borjigin, Guang‐Shun Yang, Kirk J. Wangensteen, Zhi‐Ying He, Xin Wang, Yi‐Ping Hu – 7 April 2014 – A better understanding of hepatocyte senescence could be used to treat age‐dependent disease processes of the liver. Whether continuously proliferating hepatocytes could avoid or reverse senescence has not yet been fully elucidated.

Michael L. Volk, Meghan Roney, Angela Fagerlin – 7 April 2014 – Prior studies have shown that patients are reluctant to accept donor‐specific risks, and transplant professionals lack an effective and time‐efficient means of obtaining informed consent. We designed and pilot‐tested a Web‐based patient decision aid (DA) on organ quality. The DA was administered to 53 liver transplant candidates (median Model for End‐Stage Liver Disease score = 14, range = 7‐26), and they took a mean of 15 minutes to complete it. Questions about knowledge and attitudes were asked before and after the DA.

Ashwin Balagopal, Abraham J. Kandathil, Yvonne H. Higgins, Jonathan Wood, Justin Richer, Jeffrey Quinn, Lois Eldred, Zhiping Li, Stuart C. Ray, Mark S. Sulkowski, David L. Thomas – 5 April 2014 – Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) cause substantial mortality, especially in persons chronically infected with both viruses. HIV infection raises plasma HCV RNA levels and diminishes the response to exogenous alpha interferon (IFN). The degree to which antiretroviral therapy (ART) control of infection overcomes these HIV effects is unknown.

Kohta Iguchi, Etsuro Hatano, Kenya Yamanaka, Motohiko Sato, Gen Yamamoto, Yosuke Kasai, Tatsuya Okamoto, Masayuki Okuno, Kojiro Taura, Kyoko Fukumoto, Kazuyuki Ueno, Shinji Uemoto – 4 April 2014 – Excessive portal flow to a small remnant liver or small‐for‐size graft is a primary factor of small‐for‐size syndrome. We demonstrated that olprinone (OLP), a phosphodiesterase III inhibitor, had a hepatoprotective effect in a rat extended hepatectomy model and a small‐for‐size liver transplantation model through a modification of the portal venous pressure (PVP).

Michael D. Leise, Nelson Leung, Ziad El‐Zoghby, Humberto C. Gonzalez Gonzalez, Jane H. Cerhan, Scott L. Nyberg – 4 April 2014