Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

Pierre Bedossa, the FLIP Pathology Consortium – 19 April 2014 – Biopsy is still the gold standard for the diagnosis of nonalcoholic steatohepatitis but the definition may vary among pathologists, a drawback especially in evaluation of biopsies for clinical trials. We previously developed a scoring system (steatosis, activity, fibrosis [SAF]) allowing the use of an algorithm (fatty liver inhibition of progression [FLIP]) for the classification of liver injury in morbid obesity.

Persistent viremia in human immunodeficiency virus/hepatitis B coinfected patients undergoing long‐term tenofovir: Virological and clinical implications

Anders Boyd, Joël Gozlan, Sarah Maylin, Constance Delaugerre, Gilles Peytavin, Pierre‐Marie Girard, Fabien Zoulim, Karine Lacombe – 19 April 2014 – Tenofovir (TDF) is considered the ideal treatment for patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV). However, certain coinfected patients exhibit incomplete viral suppression, with persistent, and sometimes transient, bouts of HBV replication. The reasons for this, including clinical effect, are unclear.

Iron‐induced oxidative rat liver injury after non–heart‐beating warm ischemia is mediated by tumor necrosis factor α and prevented by deferoxamine

Xianwa Niu, Wen Hua Huang, Bastiaan De Boer, Luc Delriviere, Ling Jun Mou, Gary P. Jeffrey – 19 April 2014 – This study investigated iron‐induced injury after warm ischemia in a non–heart‐beating (NHB) rat liver model and the effects of deferoxamine (DFO). Livers from heart‐beating (HB) rats or rats that were NHB for 60 minutes were stored in University of Wisconsin solution for 5 hours at 4°C [cold storage (CS)] and then were subjected to 2 hours of machine reperfusion (MRP) at 37°C.

Reply

Riad Salem, Michael Vouche, Ali Habib, Edward Kim, Kent T. Sato, Ryan Hickey, Robert Lewandowski – 19 April 2014

Long‐term effect of childhood liver transplantation on body cell mass

Looi Cheng Ee, Rebecca Joanne Hill, Kerrie Beale, Charlton Noble, Jonathan Fawcett, Geoffrey John Cleghorn – 18 April 2014 – Malnutrition is common in end‐stage liver disease, but a correction after transplantation is expected. Body cell mass (BCM) assessment using total body potassium (TBK) measurements is considered the gold standard for assessing nutritional status. The aim of this study was to examine the BCM and, therefore, nutritional status of long‐term survivors after childhood liver transplantation.

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