Donor hemodynamic profile presages graft survival in donation after cardiac death liver transplantation

Peter L. Abt, Jens Praestgaard, Sharon West, Richard Hasz – 18 October 2013 – Obligatory exposure to a period of warm ischemia is the defining feature of liver allografts from donation after cardiac death (DCD) donors. We explored novel methods for characterizing the dynamic aspects of donor warm ischemia that might be useful in assessing organ quality. The hemodynamic profile during donor warm ischemia was retrospectively studied for 110 Maastricht category III DCD donors.

Use of hepatitis B surface antigen–positive grafts in liver transplantation: A matched analysis of the US National database

Zhiwei Li, Zhenhua Hu, Jie Xiang, Jie Zhou, Sheng Yan, Jian Wu, Lin Zhou, Shusen Zheng – 18 October 2013 – The scarcity of available donor organs is the key challenge in orthotopic liver transplantation (OLT). A viable way of expanding the donor pool is the use of liver grafts from hepatitis B surface antigen (HBsAg)–positive donors.

Increasing the Donor Pool: Consideration of Prehospital Cardiac Arrest in Controlled Donation After Circulatory Death for Liver Transplantation

Ahmed H. Elaffandi, Glenn K. Bonney, Bridget Gunson, Irene Scalera, Hynek Mergental, John R. Isaac, Simon R. Bramhall, Darius F. Mirza, M. Thamara P.R. Perera, Paolo Muiesan – 18 October 2013 – Donor warm ischemia has implications for outcomes after liver transplantation (LT) using organs from donation after circulatory death (DCD) donors. Prehospital cardiac arrest (PHCA) before donation may generate a further ischemic insult. The aim of this single‐center study of 108 consecutive DCD LT procedures was to compare the outcomes of PHCA and non‐PHCA cohorts.

Transjugular intrahepatic portosystemic shunts in liver transplant recipients

Alexander R. Bonnel, Chalermrat Bunchorntavakul, K. Rajender Reddy – 18 October 2013 – The insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a minimally invasive procedure used to relieve the signs and symptoms of portal hypertension in patients with liver disease. The most common indications for placement are refractory ascites and variceal hemorrhage. In properly selected candidates, TIPS placement can serve as a bridge to liver transplantation.

Oral mucosal health in liver transplant recipients and controls

Jaana Helenius‐Hietala, Hellevi Ruokonen, Lisa Grönroos, Harri Rissanen, Miira M. Vehkalahti, Liisa Suominen, Helena Isoniemi, Jukka H. Meurman – 18 October 2013 – Immunosuppressive drugs and other medications may predispose patients to oral diseases. Data on oral mucosal health in recipients of liver transplantation (LT) are limited. We, therefore, recruited 84 LT recipients (64 with chronic liver disease and 20 with acute liver failure) for clinical oral examinations in a cross‐sectional, case‐control study. Their oral health had been clinically examined before transplantation.

Racial and socioeconomic disparities in pediatric and young adult liver transplant outcomes

Rekha V. Thammana, Stuart J. Knechtle, Rene Romero, Thomas G. Heffron, Caroline T. Daniels, Rachel E. Patzer – 17 October 2013 – Racial and socioeconomic disparities exist in liver transplantation (LT) outcomes among adults, but little research exists for pediatric LT populations. We examined racial differences in graft survival and mortality within a retrospective cohort of pediatric and young adult LT recipients at a large children's transplant center in the Southeast between 1998 and 2011.

Combined lung and liver transplantation: Analysis of a single‐center experience

Stephanie G. Yi, Sherilyn Gordon Burroughs, Matthias Loebe, Scott Scheinin, Harish Seethamraju, Soma Jyothula, Howard Monsour, Robert McFadden, Hemangshu Podder, Ashish Saharia, Emad H. Asham, Maha Boktour, A. Osama Gaber, R. Mark Ghobrial – 17 October 2013 – Patients with end‐stage lung disease complicated by cirrhosis are not expected to survive lung transplantation alone. Such patients are potential candidates for combined lung‐liver transplantation (CLLT), however few reports document the indications and outcomes after CLLT. This is a review of a large single‐center CLLT series.

Aerobic capacity during cardiopulmonary exercise testing and survival with and without liver transplantation for patients with chronic liver disease

William Bernal, Rosa Martin‐Mateos, Miklós Lipcsey, Caroline Tallis, Kyne Woodsford, Mark J. Mcphail, Christopher Willars, Georg Auzinger, Elizabeth Sizer, Michael Heneghan, Simon Cottam, Nigel Heaton, Julia Wendon – 17 October 2013 – Chronic liver disease (CLD) is associated with muscle wasting, reduced exercise tolerance and aerobic capacity (AC). Measures of AC determined with cardiopulmonary exercise testing (CPET) may predict survival after liver transplantation (LT), but the relationship with nontransplant outcomes is uncertain.

Regional perfusion by extracorporeal membrane oxygenation of abdominal organs from donors after circulatory death: A systematic review

Iestyn M. Shapey, Paolo Muiesan – 17 October 2013 – Organs from donors after circulatory death (DCDs) are particularly susceptible to the effects of warm ischemia injury. Regional perfusion (RP) by extracorporeal membrane oxygenation (ECMO) is increasingly being advocated as a useful remedy to the effects of ischemia/reperfusion injury, and it has been reported to enable the transplantation of organs from donors previously deemed unsuitable. The MEDLINE, Embase, and Cochrane databases were searched, and articles published between 1997 and 2013 were obtained.

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