Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Yasuhito Arai, Yasushi Totoki, Fumie Hosoda, Tomoki Shirota, Natsuko Hama, Hiromi Nakamura, Hidenori Ojima, Koh Furuta, Kazuaki Shimada, Takuji Okusaka, Tomoo Kosuge, Tatsuhiro Shibata – 9 October 2013 – Cholangiocarcinoma is an intractable cancer, with limited therapeutic options, in which the molecular mechanisms underlying tumor development remain poorly understood. Identification of a novel driver oncogene and applying it to targeted therapies for molecularly defined cancers might lead to improvements in the outcome of patients.

Diagnostic accuracy of 18F‐methylcholine positron emission tomography/computed tomography for intra‐ and extrahepatic hepatocellular carcinoma

Matthanja Bieze, Heinz‐Josef Klümpen, Joanne Verheij, Ulrich Beuers, Saffire S.K.S. Phoa, Thomas M. van Gulik, Roelof J. Bennink – 9 October 2013 – Diagnosis of hepatocellular carcinoma (HCC) primarily involves imaging. The aim of this study was to assess the accuracy of 18F‐fluorocholine (18F‐FCH) positron emission tomography (PET) for detection of HCC and evaluation of extent of disease. Patients with HCC >1 cm were included between 2009 and July 2011, and follow‐up closed in February 2013.

Creatinine‐ versus cystatine C‐based equations in assessing the renal function of candidates for liver transplantation with cirrhosis

Vandréa De Souza, Aoumeur Hadj‐Aissa, Olga Dolomanova, Muriel Rabilloud, Nicolas Rognant, Sandrine Lemoine, Sylvie Radenne, Jérôme Dumortier, Colette Chapuis‐Cellier, Françoise Beyerle, Chantal Bon, Jean Iwaz, Luciano Selistre, Laurence Dubourg – 9 October 2013 – Renal dysfunction is frequent in liver cirrhosis and is a strong prognostic predictor of orthotopic liver transplantation (OLT) outcome. Therefore, an accurate evaluation of the glomerular filtration rate (GFR) is crucial in pre‐OLT patients.

Small proline rich protein 2a in benign and malignant liver disease

Yoshiaki Mizuguchi, Kumiko Isse, Susan Specht, John G. Lunz, Natasha Corbitt, Toshihiro Takizawa, Anthony J. Demetris – 9 October 2013 – STAT3‐driven expression of small proline rich protein 2a (SPRR2a), which acts as an src homology 3 (SH3) domain ligand, induces biliary epithelial cell (BEC) epithelial‐mesenchymal transition (EMT), which, in turn, promotes wound healing. SPRR2a also quenches free radicals and protects against oxidative stress and DNA damage in nonneoplastic BEC. Sprr2a‐induced EMT also increases local invasiveness of cholangiocarcinomas (CC), but prevents metastases.

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