Small proline rich protein 2a in benign and malignant liver disease

Yoshiaki Mizuguchi, Kumiko Isse, Susan Specht, John G. Lunz, Natasha Corbitt, Toshihiro Takizawa, Anthony J. Demetris – 9 October 2013 – STAT3‐driven expression of small proline rich protein 2a (SPRR2a), which acts as an src homology 3 (SH3) domain ligand, induces biliary epithelial cell (BEC) epithelial‐mesenchymal transition (EMT), which, in turn, promotes wound healing. SPRR2a also quenches free radicals and protects against oxidative stress and DNA damage in nonneoplastic BEC. Sprr2a‐induced EMT also increases local invasiveness of cholangiocarcinomas (CC), but prevents metastases.

An effective interferon‐gamma‐mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus‐positive patients

Pavlos Kokordelis, Benjamin Krämer, Christian Körner, Christoph Boesecke, Esther Voigt, Patrick Ingiliz, Andreas Glässner, Marianne Eisenhardt, Franziska Wolter, Dominik Kaczmarek, Hans Dieter Nischalke, Jürgen K. Rockstroh, Ulrich Spengler, Jacob Nattermann – 8 October 2013 – Hepatitis C virus (HCV) coinfection is an increasing health problem in human immunodeficiency virus‐positive (HIV+) individuals. However, a considerable proportion of HIV+ patients manage to overcome acute hepatitis C (AHC) spontaneously.

Hepatic interferon‐stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin‐28B genotypes

Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Akito Sakai, Rika Horii, Kuniaki Arai, Tatsuya Yamashita, Yoshio Sakai, Taro Yamashita, Hikari Okada, Kazuhisa Murai, Mikiko Nakamura, Eishiro Mizukoshi, Shuichi Kaneko – 8 October 2013 – Pretreatment up‐regulation of hepatic interferon (IFN)‐stimulated genes (ISGs) has a stronger association with the treatment‐resistant interleukin (IL)28B minor genotype (MI; TG/GG at rs8099917) than with the treatment‐sensitive IL28B major genotype (MA; TT at rs8099917).

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