Small proline rich protein 2a in benign and malignant liver disease
Yoshiaki Mizuguchi, Kumiko Isse, Susan Specht, John G. Lunz, Natasha Corbitt, Toshihiro Takizawa, Anthony J. Demetris – 9 October 2013 – STAT3‐driven expression of small proline rich protein 2a (SPRR2a), which acts as an src homology 3 (SH3) domain ligand, induces biliary epithelial cell (BEC) epithelial‐mesenchymal transition (EMT), which, in turn, promotes wound healing. SPRR2a also quenches free radicals and protects against oxidative stress and DNA damage in nonneoplastic BEC. Sprr2a‐induced EMT also increases local invasiveness of cholangiocarcinomas (CC), but prevents metastases.