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Tetsuya Hosaka, Fumitaka Suzuki, Hiromitsu Kumada – 7 October 2013
Tri‐iodothyronine induces hepatocyte proliferation by protein kinase a‐dependent β‐catenin activation in rodents
Maura Fanti, Sucha Singh, Giovanna M. Ledda‐Columbano, Amedeo Columbano, Satdarshan P. Monga – 7 October 2013 – Thyroid hormone (T3), like many other ligands of the steroid/thyroid hormone nuclear receptor superfamily, is a strong inducer of liver cell proliferation in rats and mice. However, the molecular basis of its mitogenic activity, which is currently unknown, must be elucidated if its use in hepatic regenerative medicine is to be considered. F‐344 rats or C57BL/6 mice were fed a diet containing T3 for 2‐7 days.
Ascites and serum sodium are markers of increased waiting list mortality in children with chronic liver failure
Renata Pugliese, Eduardo A. Fonseca, Gilda Porta, Vera Danesi, Teresa Guimaraes, Adriana Porta, Irene K. Miura, Cristian Borges, Helry Candido, Marcel Benavides, Flavia H. Feier, Andre Godoy, Rita Antonelli Cardoso, Mario Kondo, Paulo Chapchap, Joao Seda Neto – 7 October 2013 – Ascites is the most common complication of cirrhosis and in adults it is associated with 50% mortality at 5 years if patients do not receive a liver transplant. The occurrence of hyponatremia in these patients has been associated with increased mortality on the waiting list.
Individualized treatment for patients with low HCV load (Genotype 1): A viral kinetic approach
Harel Dahari, Scott J. Cotler – 6 October 2013
Hemodynamic changes in the hepatic circulation after the modulation of the splenic circulation in an in vivo human experimental model
Nobuhisa Akamatsu, Yasuhiko Sugawara, Shouichi Satou, Tetsuya Mitsui, Riki Ninomiya, Masahiko Komagome, Fumiaki Ozawa, Yoshifumi Beck – 4 October 2013 – Recent advances in liver surgery have highlighted the effects of the splenic circulation on the hepatic circulation with respect to the hepatic arterial buffer response (HABR). The aim of the present study was to investigate the actual hemodynamic effects of splenic artery embolization/ligation and splenectomy on the hepatic circulation in patients who underwent pancreaticoduodenectomy through in vivo experimental models.
Hepatitis E infection in liver transplant recipients
Alberto Unzueta, Jorge Rakela – 4 October 2013 – Hepatitis E virus (HEV) infection (genotype 3) has been described in developed countries as a cause of chronic hepatitis in recipients of solid organ transplantation (SOT), with the first cases reported in 2008. Immunosuppression seems to play a major role in the pathogenesis of chronic infections. The current gold standard for the diagnosis of HEV infection is the detection of HEV RNA in serum, stools, or both.
“No one really knows why they are alive until they know what they'd die for”: Lessons from the death of a living liver donor
Michael Crawford, Geoffrey McCaughan – 4 October 2013
Early‐onset and late‐onset heart failure after liver transplantation
Odilson M. Silvestre, Alberto Q. Farias, Fernando Bacal – 4 October 2013
Novel Death Defying Domain in met entraps the active site of caspase‐3 and blocks apoptosis in hepatocytes
Jihong Ma, Chunbin Zou, Lida Guo, Danushka S. Seneviratne, Xinping Tan, Yong‐Kook Kwon, Jiyan An, Robert Bowser, Marie C. DeFrances, Reza Zarnegar – 3 October 2013 – Met, the transmembrane tyrosine kinase receptor for hepatocyte growth factor (HGF), is known to function as a potent antiapoptotic mediator in normal and neoplastic cells. Herein we report that the intracellular cytoplasmic tail of Met has evolved to harbor a tandem pair of caspase‐3 cleavage sites, which bait, trap, and disable the active site of caspase‐3, thereby blocking the execution of apoptosis.